59824-23-6

Basic information

• Product Name: 2-(4-CYANOPHENYL)ACETOPHENONE
• Synonyms: 2-(4-CYANOPHENYL)ACETOPHENONE;Benzonitrile, 4-(2-oxo-2-phenylethyl)-
• CAS NO: 59824-23-6
• Molecular Formula: C₁₅H₁₁NO
• Molecular Weight: 221.25
• Mol File: 59824-23-6.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 396.3°Cat760mmHg
• Flash Point: 193.5°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 1.73E-06mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 2-(4-CYANOPHENYL)ACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CYANOPHENYL)ACETOPHENONE(59824-23-6)
• EPA Substance Registry System: 2-(4-CYANOPHENYL)ACETOPHENONE(59824-23-6)

Safety Data

• Hazardous Substances Data: 59824-23-6(Hazardous Substances Data)

Usage

General Description

2-(4-Cyanophenyl)acetophenone is a chemical compound with the molecular formula C16H13NO. It is a yellow solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. 2-(4-CYANOPHENYL)ACETOPHENONE is classified as a ketone, with a cyanophenyl group attached to the second position of the acetophenone structure. It is primarily used as a reagent in organic synthesis reactions, and it can also be employed as a building block in the production of various chemical compounds. Additionally, 2-(4-Cyanophenyl)acetophenone may also have applications in research and development, particularly in the fields of medicinal and pharmaceutical chemistry.

InChI:InChI=1/C15H11NO/c16-11-13-8-6-12(7-9-13)10-15(17)14-4-2-1-3-5-14/h1-9H,10H2

Upstream product

• 5462-71-5 4-cyanophenylacetic acid 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 623-00-7 4-bromobenzenecarbonitrile 
• 603-35-0 triphenylphosphine 
• 100-39-0 benzyl bromide 
• 17201-43-3 4-cyanobenzyl bromide 
• 74-89-5 methylamine 
• 14452-30-3 3'-iodoacetophenone 
• 13329-40-3 4-Iodoacetophenone 
• 4747-13-1 α-methoxystyrene 
• 3058-39-7 4-iodobenzonitrile 
• 29822-79-5 4-(2-phenylethynyl)benzonitrile 
• 98-86-2 acetophenone 
• 873-74-5 4-Aminobenzonitrile 

Downstream Products

• 346623-13-0 α'-oxo-bibenzyl-4-carboxylic acid 
• 36803-56-2 4-(2-(4-methoxyphenyl)-2-oxoacetyl)benzonitrile 
• 1286715-76-1 C₁₈H₁₆N₂O 
• 93-99-2 benzoic acid phenyl ester 
• 76284-88-3 4-(2-benzoxazolylmethyl)benzonitrile 
• 1593235-38-1 4-(6-chloro-2-benzoxazolylmethyl)benzonitrile 
• 1593235-37-0 4-(6-methyl-2-benzoxazolylmethyl)benzonitrile 
• 2005-08-5 4-chlorophenyl benzoate 
• 1593235-56-3 4-(p-cyanobenzyl)quinazoline 
• 1593235-36-9 4-(5-phenyl-2-benzoxazolylmethyl)benzonitrile 
• 1593235-54-1 2-(p-cyanobenzyl)-5-pyridinecarbonitrile 
• 1593235-52-9 4-(5-acetyl-2-furylmethyl)benzonitrile 
• 1593235-51-8 5-(p-cyanobenzyl)-2-thiophenecarbonitrile 
• 1593235-50-7 4-(5-acetyl-2-thienylmethyl)benzonitrile 

Relevant articles and documents

Photoinduced Cross-Coupling of Aryl Iodides with Alkenes

A protocol for photoinduced cross-coupling of aryl iodides having polar π-functional groups or elongated π-conjugation with alkenes has been developed. The radical cascade mechanism involving generation of aryl radicals via C-I bond homolysis of photoexcited aryl iodides and their subsequent addition to alkenes is proposed. The method enables iodide-selective cross-coupling over other halogen leaving groups with functional group compatibility on both arene and alkene motifs.

A family of low molecular-weight, organic catalysts for reductive C-C bond formation

Hydrazines form a new family of low molecular-weight reducing agents for diazonium salts. Using only small amounts of hydrazine catalyst, the coupling of diazonium salts to a variety of reactive partners has been achieved, without the requirement for either metal adjuvants or irradiation with visible or ultraviolet light. The generality of the concept proposed herein as well as its advantages in the preparative scale is outlined and discussed.

An expedient route to heterocycles through α-arylation of ketones and arylamides by microwave induced thermal SRN1 reactions

Microwave irradiation promotes a quick aromatic nucleophilic substitution by a thermally induced electron transfer process to form new C-C bonds by the coupling of aryl radicals and enolate nucleophiles. Diverse 2-aryl-1- phenylethanones can be prepared by the direct α-arylation of acetophenone with different haloarenes. The ketone enolate anion is generated by deprotonation with tBuOK in DMSO and the reaction is carried out in a closed microwave vessel at 70-100°C for 10 min. This simple procedure also allows the synthesis of deoxybenzoin and indole heterocycle derivatives by inter- or intra-molecular ring closure reactions, with moderate to excellent substitution yields. This journal is the Partner Organisations 2014.