62059-61-4

Usage

Physical state

Yellowish liquid

Odor

Slightly floral

Common uses

Building block in the synthesis of pharmaceuticals and other organic compounds

Versatility

Versatile intermediate in organic chemistry

Production

Used in the production of various specialty chemicals

Research and development

Starting material for the synthesis of complex organic molecules

Biological and pharmacological activities

Potential activities have been studied

Upstream product

• 51499-41-3 hexanoic acid bromide 
• 1004-22-4 (phenylethynyl)sodium 
• 2051-49-2 n-hexanoic anhydride 
• 1119-67-1 1-iodo-1-hexyne 
• 4440-01-1 lithium phenylacetylide 
• 27975-79-7 1-phenyloct-1-yn-3-ol 
• 16967-02-5 1-phenyl-1-octyne 
• 1006722-47-9 C₁₁H₂₀O₃ 
• 536-74-3 phenylacetylene 
• 66-25-1 hexanal 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 123-66-0 Ethyl hexanoate 
• 21890-32-4 tetrakis(phenylethynyl)tin 
• 142-61-0 Hexanoyl chloride 

Downstream Products

• 14633-16-0 3-pentyl-5-phenylisoxazole 
• 108161-55-3 (E)-1-Iodo-1-phenyl-oct-1-en-3-one 
• 108161-54-2 (1Z)-1-iodo-1-phenyl-1-octen-3-one 
• 1028440-28-9 1-(5-phenyl-1H-[1,2,3]triazol-4-yl)hexan-1-one 
• 22089-86-7 Phenyl-1,2-heptanedione 
• 29478-39-5 (E)-1-phenyloct-1-en-3-one 
• 56438-78-9 (Z)-1-Phenyloct-1-en-3-on 

Relevant academic research and scientific papers

Bifunctional Borane Catalysis of a Hydride Transfer/Enantioselective [2+2] Cycloaddition Cascade

Herein, we present a mild and efficient method for synthesizing enantioenriched tetrahydroquinoline-fused cyclobutenes through a cascade reaction between 1,2-dihydroquinolines and alkynones with catalysis by chiral spiro-bicyclic bisboranes. The bisborane

Alkynylation of Csp2 (O)–H Bonds Enabled by Photoredox-Mediated Hydrogen-Atom Transfer

The development of new hydrogen-atom transfer (HAT) strategies within the framework of photoredox catalysis is highly appealing for its power to activate a desired C?H bond in the substrate leading to its selective functionalization. Reported here is the first photoredox-mediated hydrogen-atom transfer method for the efficient synthesis of ynones, ynamides, and ynoates with high regio- and chemoselectivity by direct functionalization of Csp2 (O)?H bonds. The broad synthetic application of this method has been demonstrated by the selective functionalization of C(O)?H bonds within complex molecular scaffolds.

Oxidative coupling of tetraalkynyltin with aldehydes leading to alkynyl ketones

The reaction of tetraalkynyltin with aldehydes was studied for the first time. The reaction was shown to proceed as a tandem process of nucleophilic addition of tin acetylide to aldehyde followed by Oppenauer-type oxidation of produced tin alcoholates, an

Solvent free synthesis of ynones using magnetically recoverable Copper-ferrite nanoparticles

A general and efficient biogenic CuFe2O4 MNP's catalyzed synthesis of ynones has been reported for the first time. The reaction occurs in solvent free conditions without the use of any harsh conditions. The average diameter of the na

Synthesis of 3-carbonyl pyrazole-5-phosphonates via 1,3-dipolar cycloaddition of Bestmann-Ohira reagent with ynones

The present work explores the hitherto unexplored reactivity of ynones as dipolarophiles with Bestmann-Ohira reagent. The reaction offers a convenient route for the synthesis of regioisomerically pure 3,5-disubstituted or 3,4,5-trisubstituted pyrazoles in

Synthesis of 3-carbonyl pyrazole-5-phosphonates via 1,3-dipolar cycloaddition of Bestmann-Ohira reagent with ynones

The present work explores the hitherto unexplored reactivity of ynones as dipolarophiles with Bestmann-Ohira reagent. The reaction offers a convenient route for the synthesis of regioisomerically pure 3,5-disubstituted or 3,4,5-trisubstituted pyrazoles in

Effective partial alkynylation of carboxylic acid derivatives to alkynyl ketones

The reaction of carboxylic acid derivatives such as esters, acid chlorides and acid anhydrides with alkynyl lithiums in the presence of lithium morpholinide and BF3.OEt2 gave alkynyl ketones in good yield (73-96%).

Propargylic oxidations catalyzed by dirhodium caprolactamate in water: Efficient access to α,β-acetylenic ketones

(Chemical Equation Presented) Dirhodium(II) caprolactamate (1, Rh 2(cap)4) with 70% w/w aqueous tert-butyl hydroperoxide (T-HYDRO) is a highly effective catalytic oxidation protocol for the selective C-H oxidation of alkynes to propargylic ketones. The oxidation occurs readily in aqueous solvent under mild conditions with an inexpensive and easily handled oxidant. α,β-Acetylenic carbonyl compounds are formed in up to 80% isolated yield.

Zeolite-catalyzed oxidation of benzylic and acetylenic alcohols with t-butyl hydroperoxide

4 A molecular sieves catalyze the mild conversion of activated secondary alcohols into the corresponding carbonyl compounds with t-butyl hydroperoxide (TBHP).