62066-31-3

Upstream product

• 62044-37-5 4-cyanophenylacetic acid chloride 
• 108-90-7 chlorobenzene 
• 5462-71-5 4-cyanophenylacetic acid 
• 17201-43-3 4-cyanobenzyl bromide 
• 59824-23-6 4-(2-oxo-2-phenylethyl)benzonitrile 
• 6961-42-8 4-chlorophenyl 4-chlorobenzoate 
• 1387574-33-5 octyl p-cyanophenylmethyl ketone 

Relevant academic research and scientific papers

Synthesis of Diarylacetylenes Bearing Electron-Withdrawing Groups via the Smiles Rearrangement

Nitrobenzyl benzothiazol-2-yl sulfones and nitrobenzyl 1-phenyl-1 H -tetrazol-5-yl sulfones react with chlorides of aromatic acids to form β-acyl derivatives. These products undergo the Smiles rearrangement resulting in the formation of the corresponding nitrophenyl arylacetylenes in 50-60% overall yields (approx. 75% per step). Sulfones bearing CF 3 or CN groups instead of a NO 2 substituent form mixtures of the acetylenes in moderate yields and benzyl aryl ketones in yields above 40%.

Rhodium-catalyzed acyl-transfer reaction between benzyl ketones and thioesters: Synthesis of unsymmetric ketones by ketone CO-C bond cleavage and intermolecular rearrangement

In the presence of catalytic amounts of RhH(CO)(PPh3) 3 and 1,2-bis(diphenylphosphino)benzene (dppBz), acyl groups were transferred between benzyl ketones and thioesters/aryl esters. The rhodium complex catalyzed the cleavage of keto