620949-07-7

Upstream product

• 620949-06-6 [(2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-3-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-acetonitrile 
• 620949-25-9 [(2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-3-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-methanol 
• 620949-05-5 (4aR,6S,7R,8aS)-2,2-Di-tert-butyl-6-vinyl-hexahydro-1,3,5-trioxa-2-sila-naphthalen-7-ol 
• 602301-75-7 (2R,4aR,6S,7R,8aS)-7-Benzyloxy-6-benzyloxymethyl-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine 
• 620949-24-8 (2R,4aR,6S,7R,8aS)-6-Hydroxymethyl-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol 
• 602301-65-5 (2R,4aR,6S,7R,8aS)-2-(4-Methoxy-phenyl)-6-vinyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol 
• 100-39-0 benzyl bromide 
• 85272-31-7 di-tert-butylsilyl bis(trifluoromethanesulfonate) 
• 620949-03-3 (4aR,6S,7R,8aS)-2,2-Di-tert-butyl-6-(2-hydroxy-ethyl)-hexahydro-1,3,5-trioxa-2-sila-naphthalen-7-ol 
• 620949-04-4 [(2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-3-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-acetaldehyde 

Downstream Products

• 620949-13-5 1-[(2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-3-(naphthalen-2-ylmethoxy)-tetrahydro-pyran-2-yl]-2-((4aR,6S,7R,8aS)-2,2-di-tert-butyl-6-vinyl-hexahydro-1,3,5-trioxa-2-sila-naphthalen-7-yloxy)-hex-5-en-3-ol 
• 620949-32-8 3-[(2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-3-(naphthalen-2-ylmethoxy)-tetrahydro-pyran-2-yl]-2-[(4aR,6S,7R,8aS)-2,2-di-tert-butyl-6-(2-hydroxy-ethyl)-hexahydro-1,3,5-trioxa-2-sila-naphthalen-7-yloxy]-propionitrile 
• 620949-22-6 (4aR,5aS,9S,10aR,11aS)-9-[(2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-3-(naphthalen-2-ylmethoxy)-tetrahydro-pyran-2-ylmethyl]-2,2-di-tert-butyl-octahydro-1,3,5,10-tetraoxa-2-sila-cyclohepta[b]naphthalen-8-one 
• 620949-26-0 5-[(2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-3-(naphthalen-2-ylmethoxy)-tetrahydro-pyran-2-yl]-4-((4aR,6S,7R,8aS)-2,2-di-tert-butyl-6-vinyl-hexahydro-1,3,5-trioxa-2-sila-naphthalen-7-yloxy)-pent-1-en-3-ol 
• 620949-17-9 (4aR,5aS,8S,9S,10aR,11aS)-9-[(2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-3-(naphthalen-2-ylmethoxy)-tetrahydro-pyran-2-ylmethyl]-2,2-di-tert-butyl-4,4a,5a,8,9,10a,11,11a-octahydro-1,3,5,10-tetraoxa-2-sila-cyclohepta[b]naphthalen-8-ol 
• 620949-10-2 3-[(2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-3-(naphthalen-2-ylmethoxy)-tetrahydro-pyran-2-yl]-2-((4aR,6S,7R,8aS)-2,2-di-tert-butyl-6-vinyl-hexahydro-1,3,5-trioxa-2-sila-naphthalen-7-yloxy)-propionitrile 
• 620949-19-1 (4aR,5aS,9S,10aR,11aS)-9-[(2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-3-(naphthalen-2-ylmethoxy)-tetrahydro-pyran-2-ylmethyl]-2,2-di-tert-butyl-4,4a,5a,10a,11,11a-hexahydro-1,3,5,10-tetraoxa-2-sila-cyclohepta[b]naphthalen-8-one 
• 620949-09-9 (4aR,5aS,10aR,11aS)-9-[(2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-3-(naphthalen-2-ylmethoxy)-tetrahydro-pyran-2-ylmethyl]-2,2-di-tert-butyl-octahydro-1,3,5,8,10-pentaoxa-2-sila-cyclohepta[b]naphthalene 
• 620949-12-4 3-[(2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-3-(naphthalen-2-ylmethoxy)-tetrahydro-pyran-2-yl]-2-((4aR,6S,7R,8aS)-2,2-di-tert-butyl-6-vinyl-hexahydro-1,3,5-trioxa-2-sila-naphthalen-7-yloxy)-propionaldehyde 
• 620949-28-2 (4aR,5aS,9S,10aR,11aS)-9-((2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-3-hydroxy-tetrahydro-pyran-2-ylmethyl)-2,2-di-tert-butyl-4,4a,5a,10a,11,11a-hexahydro-1,3,5,10-tetraoxa-2-sila-cyclohepta[b]naphthalen-8-one 
• 620949-08-8 (2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-2-((4aR,5aS,10aR,11aS)-2,2-di-tert-butyl-octahydro-1,3,5,8,10-pentaoxa-2-sila-cyclohepta[b]naphthalen-9-ylmethyl)-tetrahydro-pyran-3-ol 

Relevant academic research and scientific papers

Convergent synthesis of trans-fused 6/n/6/6 (n=7, 8) tetracyclic ether system via α-cyano ethers

A convergent method for synthesizing 6/n/6/6 (n=7, 8) tetracyclic ether system via two-rings construction of the central n/6 ring system was developed. The key steps of the present synthesis involve a ring-closing metathesis reaction for the construction of the seven- and eight-membered rings, and reductive etherification for the tetrahydropyrans. Unification of the two fragments through acetal formation, followed by regioselective cleavage of the acetal using TMSCN/TMSOTf in the presence of 2,6-di-tert-butyl-4-methylpyridine, afforded the α-cyano ether, of which the nitrile group was manipulated to give the precursors of the ring-closing reactions.