620957-75-7

Upstream product

• 364385-54-6 (1S,2R)-2-tert-Butoxycarbonylamino-cyclohexylamine 
• 39576-82-4 6-methyl-2,4-dichloroquinazoline 
• 620957-79-1 tert-butyl [(1R,2S)-2-((2-[(4-methoxybenzyl)amino]-6-methylquinazolin-4-yl)amino)cyclohexyl]carbamate 
• 620957-77-9 tert-butyl ((1R,2S)-2-[(2-chloro-6-methylquinazolin-4-yl)amino]cyclohexyl)carbamate 
• 620957-80-4 (1R,2S)-2-[(2-amino-6-methylquinazolin-4-yl)amino]-cyclohexylamine 
• 152120-54-2 N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine 

Downstream Products

• 1123685-30-2 N-[(1R,2S)-2-((2-[(4-chlorophenyl)carbonyl]amino-6-methylquinazolin-4-yl)amino)cyclohexyl]-N',N-bis(tert-butoxycarbonyl)guanidine 

Relevant academic research and scientific papers

Discovery and structure-activity relationships of 4-aminoquinazoline derivatives, a novel class of opioid receptor like-1 (ORL1) antagonists

Synthesis and structure-activity relationship studies of a series of 4-aminoquinazoline derivatives led to the identification of (1R,2S)-17, N-[(1R,2S)-2-({2-[(4-chlorophenyl)carbonyl]amino-6-methylquinazolin-4-yl}amino)cyclohexyl]guanidine dihydrochloride, as a highly potent ORL1 antagonist with up to 3000-fold selectivity over the μ, δ, and κ opioid receptors. Molecular modeling clarified the structural factors contributing to the high affinity and selectivity of (1R,2S)-17.

QUINAZOLINE DERIVATIVE AND MEDICINE

An object of the present invention is to provide an antipruritic agent having a novel action mechanism. The present invention provides an antipruritic agent comprising a compound represented by the following general formula (1): wherein R1 repr

ANTIPRURITICS

The present invention relates to an antipruritic agent comprising a nociceptin antagonist as an active ingredient. The nociceptin antagonist can be used as a preventive or remedy for diseases associated with itching (for example, atopic dermatitis and urticaria), local pruritus cutaneous caused by insect excretion and secretion, nodular prurigo, kidney dialysis, diabetes, blood disease, liver disease, kidney disease, incretion and metabolic disorder, viscera malignant tumor, hyperthyroidism, autoimmune disease, multiple sclerosis, neurologic disease, psychoneurosis, allergic conjunctivitis, spring catarrh, atopic keratoconjunctivitis, or itching caused by excess use of laxuries and drugs because it has excellent scrtaching behavior suppressing effect, that is, antiitching effect and antipruritic effect.