620963-03-3Relevant academic research and scientific papers
Design, synthesis and evaluation of novel diaryl urea derivatives as potential antitumor agents
Lu, Chenshu,Tang, Ke,Li, Yan,Li, Peng,Lin, Ziyun,Yin, Dali,Chen, Xiaoguang,Huang, Haihong
, p. 351 - 360 (2014/04/17)
A novel series of diaryl ureas containing different linker groups were designed and synthesized. Their in vitro antitumor activity against MX-1, A375, HepG2, Ketr3 and HT-29 was evaluated using the standard MTT assay. Compounds having a rigid linker group such as vinyl, ethynyl and phenyl showed significant inhibitory activity against a variety of cancer cell lines. Specifically, compound 23 with a phenyl linker group demonstrated broad-spectrum antitumor activity with IC50 values of 5.17-6.46 μM against five tested tumor cell lines. Compound 23 is more potent than reference drug sorafenib (8.27-15.2 μM), representing a promising lead for further optimization.
