Welcome to LookChem.com Sign In|Join Free

CAS

  • or
4'-Nitro-3-biphenylcarboxylic acid is a chemical compound with the molecular formula C13H9NO4. It is a derivative of biphenyl and carboxylic acid, featuring a nitro group attached to the 4' position of the biphenyl ring. 4'-Nitro-3-biphenylcarboxylic acid is known for its role in the synthesis of other organic compounds and pharmaceutical products, as well as its potential applications as a detection agent for alkali and alkaline earth metal ions. Furthermore, it has been studied for its potential use in the design of new materials and as a catalyst in organic reactions, making it a compound of interest in the fields of chemistry and materials science.

729-01-1

Post Buying Request

729-01-1 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

729-01-1 Usage

Uses

Used in Pharmaceutical Synthesis:
4'-Nitro-3-biphenylcarboxylic acid is used as a key intermediate in the synthesis of various pharmaceutical products. Its unique structure allows it to be a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
As a derivative of biphenyl and carboxylic acid, 4'-Nitro-3-biphenylcarboxylic acid is utilized as a starting material or intermediate in the synthesis of a wide range of organic compounds. Its versatility in chemical reactions makes it a useful component in the creation of complex organic molecules.
Used as a Detection Agent:
4'-Nitro-3-biphenylcarboxylic acid is used as a detection agent for alkali and alkaline earth metal ions. Its chemical properties enable it to selectively interact with these metal ions, making it a valuable tool in analytical chemistry for the identification and quantification of these elements.
Used in Material Science:
4'-Nitro-3-biphenylcarboxylic acid has been studied for its potential use in the design of new materials. Its unique structure and properties may contribute to the development of advanced materials with specific characteristics for various applications in industries such as electronics, aerospace, and automotive.
Used as a Catalyst in Organic Reactions:
4'-Nitro-3-biphenylcarboxylic acid has been investigated for its potential use as a catalyst in organic reactions. Its ability to facilitate chemical transformations can improve the efficiency and selectivity of various organic synthesis processes, making it a valuable asset in the field of catalysis.

Check Digit Verification of cas no

The CAS Registry Mumber 729-01-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,2 and 9 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 729-01:
(5*7)+(4*2)+(3*9)+(2*0)+(1*1)=71
71 % 10 = 1
So 729-01-1 is a valid CAS Registry Number.

729-01-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(4-nitrophenyl)benzoic acid

1.2 Other means of identification

Product number -
Other names 4'-Nitro-3-biphenylcarboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:729-01-1 SDS

729-01-1Relevant articles and documents

Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents

Chiarelli, Laurent R.,Mori, Matteo,Barlocco, Daniela,Beretta, Giangiacomo,Gelain, Arianna,Pini, Elena,Porcino, Marianna,Mori, Giorgia,Stelitano, Giovanni,Costantino, Luca,Lapillo, Margherita,Bonanni, Davide,Poli, Giulio,Tuccinardi, Tiziano,Villa, Stefania,Meneghetti, Fiorella

supporting information, p. 754 - 763 (2018/06/26)

We report on the virtual screening, synthesis, and biological evaluation of new furan derivatives targeting Mycobacterium tuberculosis salicylate synthase (MbtI). A receptor-based virtual screening procedure was applied to screen the Enamine database, identifying two compounds, I and III, endowed with a good enzyme inhibitory activity. Considering the most active compound I as starting point for the development of novel MbtI inhibitors, we obtained new derivatives based on the furan scaffold. Among the SAR performed on this class, compound 1a emerged as the most potent MbtI inhibitor reported to date (Ki = 5.3 μM). Moreover, compound 1a showed a promising antimycobacterial activity (MIC99 = 156 μM), which is conceivably related to mycobactin biosynthesis inhibition.

Design, synthesis and evaluation of novel diaryl urea derivatives as potential antitumor agents

Lu, Chenshu,Tang, Ke,Li, Yan,Li, Peng,Lin, Ziyun,Yin, Dali,Chen, Xiaoguang,Huang, Haihong

, p. 351 - 360 (2014/04/17)

A novel series of diaryl ureas containing different linker groups were designed and synthesized. Their in vitro antitumor activity against MX-1, A375, HepG2, Ketr3 and HT-29 was evaluated using the standard MTT assay. Compounds having a rigid linker group such as vinyl, ethynyl and phenyl showed significant inhibitory activity against a variety of cancer cell lines. Specifically, compound 23 with a phenyl linker group demonstrated broad-spectrum antitumor activity with IC50 values of 5.17-6.46 μM against five tested tumor cell lines. Compound 23 is more potent than reference drug sorafenib (8.27-15.2 μM), representing a promising lead for further optimization.

Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA)

Venkatraj, Muthusamy,Messagie, Jonas,Joossens, Jurgen,Lambeir, Anne-Marie,Haemers, Achiel,Van Der Veken, Pieter,Augustyns, Koen

supporting information; experimental part, p. 1557 - 1568 (2012/04/17)

Recent drug discovery programs targeting urokinase plasminogen activator (uPA) have resulted in nonpeptidic inhibitors consisting of amidine or guanidine functional groups attached to aromatic or heteroaromatic scaffolds. There is a general problem of poor oral bioavailability of these charged inhibitors. In this paper, we report the synthesis and evaluation of a series of naphthamide and naphthalene sulfonamides as uPA inhibitors containing non-basic groups as substitute for amidine or guanidine groups.

Biaryl derived amide modulators of vanilloid VR1 receptor

-

Page/Page column 29-30, (2010/11/24)

The invention is directed to novel vanilloid receptor type 1 (VR1) ligands. More specifically, the invention relates to novel biaryl-derived amides that are potent antagonists or agonists of VR1. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

AMINO ACIDS

-

Page/Page column 48, (2008/06/13)

Compounds of formula (I): Z’ -CO-A-B-NH-Z (I) wherein: Z is H or an amino protecting group; Z’ is OH, a protected or activated hydroxyl group or C1; A is an optionally substituted C5-6 arylene group; and B is an optionally substituted C5-6 arylene group.

Derivatives of aminobenzoic and aminobiphenylcarboxylic acids useful as anti-cancer agents

-

, (2008/06/13)

The present invention provides compounds having the formula: wherein n is0or1; R is —NH2or wherein R1and R2are independently selected from the group consisting of H, alkyl, aralkyl, heteroaralkyl, carboxy, carboxyalkyl, and carbamoyl; Q is R3C(O)— or wherein R5is selected from the group consisting of H, alkyl, aralkyl, heteroaralkyl, and carbamoylalkyl, and R3and R4are selected from the group consisting of H, alkyl, alkoxy, arylalkoxy, aralkyl, heteroaralkyl, and carbamoylalkyl; the Q—NH—(CH2)n— and the —C(O)R substituents of the compound of formula I are independently positioned ortho, meta, orpara relative to the carbon atoms that form the bond between the two phenyl groups to which said substituents are bound, with the proviso that said substituents are not both positioned ortho; and the Q—NH—(CH2)nand the —C(O)R substituents of the compound of formula II are positioned meta orpara to each other; or a biolabile ester thereof, or a pharmaceutically acceptable salt thereof. The compounds are useful for treating uPA- or uPAR-mediated disorders, e.g., tumor metastasis, tumor angiogenesis, restenosis, chronic inflammation, or corneal angiogenesis.

Inhibition of farnesyltransferase

-

, (2008/06/13)

A compound of the formula C0Bwherein C0 stands for A representing O or 2H, and R0 representing SH, NH2, or CxHy-SO2-NH-, wherein CxHy is a straight chain saturated or unsaturated hydrocarbon, with x being between 1 and 20 and y between 3 and 41, inclusive

Inhibitors of prenyl transferases

-

, (2008/06/13)

Compounds which inhibit prenyl transferases, particularly farnysyltransferase and geranylgeranyl transferase I, processes for preparing the compounds, pharmaceutical compositions containing the compounds, and methods of use.

Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors

Qian, Yimin,Vogt, Andreas,Sebti, Sa?d M.,Hamilton, Andrew D.

, p. 217 - 223 (2007/10/03)

Cysteine farnesylation of the ras oncogene product Ras is required for its transforming activity and is catalyzed by farnesyltransferase (FTase). The Ras carboxyl terminal tetrapeptide CAAX (C is cysteine, A is any aliphatic amino acid, X is methionine or serine) is the minimum sequence for FTase recognition. We report here the design, synthesis, and biological characterization of Ras CAAX non-peptide mimetics in which the cysteine is linked through a reduced pseudopeptide bond to 4-amino-3'-carboxybiphenyl. These non-peptide mimetics are potent inhibitors of FTase (IC50 = 40 nM for the most potent inhibitor) and are highly selective for FTase over GGTase I (geranylgeranyltransferase I). They are not substrates for farnesylation, do not have peptidic features, and have no hydrolyzable bonds. Structure- activity studies reveal the importance of the position of the carboxylic acid on the aryl ring as well as the reduction of the cysteine amide bond. Substitution at the 2-position of 4-amino-3'-carboxybiphenyl increases inhibitory potency, while the removal of the carboxylic acid results in a 10- fold loss of inhibitory activity.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 729-01-1