62100-49-6Relevant articles and documents
A new practical one-pot conversion of phenols to anilines
Mizuno, Masahiro,Yamano, Mitsuhisa
, p. 3629 - 3631 (2007/10/03)
(Chemical Equation Presented) A novel one-pot synthesis of anilines from phenols was developed. Using this methodology, anilines are produced in good yield (86%) by a reaction of phenols with 2-bromo-2-methylpropionamide and NaOH in DMA via Smiles rearrangement. Phenols, which are substituted electron-withdrawing groups, are more reactive for Smiles rearrangement. Thiophenols are also converted to anilines. The process is a convenient, safe, and inexpensive method for large-scale preparation of anilines.