62100-54-3

Basic information

• Product Name: N-(4-Nitrophenyl)-2-hydroxy-2-methylpropanamide
• Synonyms: 2-Hydroxy-2-methyl-N-(4-nitrophenyl)propionamide;N-(4-Nitrophenyl)-2-hydroxy-2-methylpropanamide
• CAS NO: 62100-54-3
• Molecular Formula: C₁₀H₁₂N₂O₄
• Molecular Weight: 224.21
• Mol File: 62100-54-3.mol

Chemical Properties

• Melting Point: 178-180 °C(Solv: ethanol (64-17-5))
• Boiling Point: 457.5±30.0 °C(Predicted)
• Appearance: /
• Density: 1.359±0.06 g/cm3(Predicted)
• PKA: 13.17±0.29(Predicted)
• CAS DataBase Reference: N-(4-Nitrophenyl)-2-hydroxy-2-methylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Nitrophenyl)-2-hydroxy-2-methylpropanamide(62100-54-3)
• EPA Substance Registry System: N-(4-Nitrophenyl)-2-hydroxy-2-methylpropanamide(62100-54-3)

Safety Data

• Hazardous Substances Data: 62100-54-3(Hazardous Substances Data)

Upstream product

• 17431-97-9 2-(4-nitrophenoxy)-2-methylpropanoic acid 
• 100-02-7 4-nitro-phenol 
• 62100-49-6 2-(4-Nitrophenyloxy)-2-methylpropionsaeureamid 

Downstream Products

• 100-01-6 4-nitro-aniline 

Relevant articles and documents

A new practical one-pot conversion of phenols to anilines

(Chemical Equation Presented) A novel one-pot synthesis of anilines from phenols was developed. Using this methodology, anilines are produced in good yield (86%) by a reaction of phenols with 2-bromo-2-methylpropionamide and NaOH in DMA via Smiles rearrangement. Phenols, which are substituted electron-withdrawing groups, are more reactive for Smiles rearrangement. Thiophenols are also converted to anilines. The process is a convenient, safe, and inexpensive method for large-scale preparation of anilines.

Method of treatment for prostatic cancer

Disclosed is a new treatment for men with prostatic cancer involving combination therapy of a 5α-reductase inhibitor, i.e., a 17β-substituted 4-azasteroid, a 17β-substituted non-azasteroid, 17β-acyl-3-carboxyandrost-3,5-diene, benzoylaminophenoxybutanoic acid derivative, fused benz(thio)amide or cinnamoylamide derivative, aromatic 1,2-diethers or thioethers, aromatic ortho acylaminophenoxy alkanoic acids, ortho thioalkylacylamino-phenoxy alkanoic acids, pharmaceutically acceptable salts and esters thereof, and particularly finasteride, in combination with an antiandrogen, i.e. flutamide. Pharmaceutical compositions useful for treatment are also disclosed.