62123-82-4

Basic information

• Product Name: Ethyl 2-(2-bromophenyl)-2-oxoacetate
• Synonyms: Ethyl 2-(2-bromophenyl)-2-oxoacetate;2-Bromo-oxo-benzeneacetic acid ethyl ester
• CAS NO: 62123-82-4
• Molecular Formula: C₁₀H₉BrO₃
• Molecular Weight: 257.08066
• Mol File: 62123-82-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethyl 2-(2-bromophenyl)-2-oxoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-(2-bromophenyl)-2-oxoacetate(62123-82-4)
• EPA Substance Registry System: Ethyl 2-(2-bromophenyl)-2-oxoacetate(62123-82-4)

Safety Data

• Hazardous Substances Data: 62123-82-4(Hazardous Substances Data)

Upstream product

• 50671-05-1 3-(2-bromophenyl)-3-oxopropionic acid ethyl ester 
• 583-55-1 1-Bromo-2-iodobenzene 
• 4755-77-5 Ethyl oxalyl chloride 
• 2142-69-0 2-bromophenyl methyl ketone 
• 64-17-5 ethanol 
• 26767-16-8 2-(2-bromophenyl)-2-oxoacetic acid 

Downstream Products

• 26767-16-8 2-(2-bromophenyl)-2-oxoacetic acid 
• 1392008-12-6 (R,E)-ethyl 2-(2-bromophenyl)-3-(tert-butyldiazenyl)-2-hydroxypropanoate 
• 7716-35-0 1-phenyl-1H-indazole-3-carboxylic acid ethyl ester 
• 1068161-66-9 C₁₅H₁₂Br₂N₂O₂ 

Relevant articles and documents

Stereospecific Nucleophilic Substitution with Arylboronic Acids as Nucleophiles in the Presence of a CONH Group

Stereospecific nucleophilic substitution was achieved for the first time with arylboronic acids as nucleophiles. This transition-metal-free coupling between chiral α-aryl-α-mesylated acetamides and arylboronic acids provided access to a series of chiral α,α-diaryl acetamides with excellent enantioselectivity and moderate to good yields. The CONH functionality proved to be crucial for bridging the reactants and promoting the reaction. Efficient syntheses of a cannabinoid CB1 receptor ligand, the antidepressant (S)-diclofensine, and a key chiral building block of the inhibitor implitapide were successfully accomplished by using this method.

Copper-catalyzed TEMPO oxidative cleavage of 1,3-diketones and β-keto esters for the synthesis of 1,2-diketones and α-keto esters

A copper-catalyzed efficient and practical method has been developed for the synthesis of 1,2-diketones and α-keto esters. TEMPO was used as a radical initiator and scavenger, oxidizing the cleavage of α-methylene of 1,3-diketones and β-keto esters to form 1,2-diketones and α-keto esters. This method provided a general way for the formation of 1,2-dicarbonyl compounds.

TETRAHYDROISOQUINOLIN-2-YL-(QUINAZOLIN-4-YL) METHANONE COMPOUNDS AS CANCER CELL GROWTH INHIBITORS

Tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone derivatives represented by formula (I), pharmacologically acceptable salts thereof, and compositions containing such compounds are described. Methods for treating hyperproliferative disorders by administering the compounds are also described. 1,2,3,4-tetrahydroisoquinoline derivatives for making tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone compounds are also described.

Electrochemical synthesis of the aryl α-ketoesters from acetophenones mediated by Ki

Two C-O bonds formed in one step: The oxidative coupling reaction of acetophenones with alcohol was developed by a dioxygen activation to afford α-ketoesters under electrochemical conditions. This novel transformation not only provides a simple and efficient approach to synthetize α-ketoester derivatives, but also invents a new strategy to construct a C-O bond by virtue of an anode oxidation (see scheme). Copyright