50671-05-1

Basic information

• Product Name: 3-(2-BROMO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• Synonyms: 3-(2-BROMO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER;ETHYL 3-(2-BROMOPHENYL)-3-OXOPROPANOATE;ETHYL (2-BROMOBENZOYL)ACETATE
• CAS NO: 50671-05-1
• Molecular Formula: C₁₁H₁₁BrO₃
• Molecular Weight: 271.11
• Product Categories: C10 to C11;Carbonyl Compounds;Esters;Building Blocks;C10 to C11;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 50671-05-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 323.8°C at 760 mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.417 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000256mmHg at 25°C
• Refractive Index: n20/D 1.5545(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(2-BROMO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-BROMO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER(50671-05-1)
• EPA Substance Registry System: 3-(2-BROMO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER(50671-05-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 50671-05-1(Hazardous Substances Data)

Usage

Uses

Reactant for preparation of:? ;Cambinol analogs as sirtuin inhibitors with antitumor action1? ;Quinolones and indoles by cyclodehydration2? ;N-allyl/propargyl enamine carboxylates3

InChI:InChI=1/C11H11BrO3/c1-2-15-11(14)7-10(13)8-5-3-4-6-9(8)12/h3-6H,2,7H2,1H3

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 6630-33-7 ortho-bromobenzaldehyde 
• 6148-64-7 ethyl potassium malonate 
• 90766-96-4 N-(2-bromobenzoyl)imidazole 
• 7154-66-7 2-bromobenzoic acid chloride 
• 6091-64-1 2-bromobenzoic acid ethyl ester 
• 141-78-6 ethyl acetate 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 88-65-3 2-bromobenzoic-acid 
• 119031-20-8 2-(2-bromo-benzoyl)-3-oxo-butyric acid ethyl ester 

Downstream Products

• 50670-86-5 α-Chlor-α-(2-brombenzoyl)-5-<α-(2,4-di-t-amylphenoxy)-acetylamino>-2-chloracetanilid 
• 1332622-30-6 ethyl 3-(2-bromophenyl)-2-[(4-phenylbutyl-2-amino)methylene]-3-oxopropanoate 
• 1332622-31-7 ethyl 3-(2-bromophenyl)-2-[(4-pyridinmethylamino)methylene]-3-oxopropanoate 
• 1332622-34-0 ethyl 4-oxo-1-(1-methyl-3-phenylpropyl)-1,4-dihydroquinoline-3-carboxylate 
• 1332622-38-4 4-oxo-1-(1-methyl-3-phenylpropyl)-1,4-dihydroquinoline-3-carboxylic acid 
• 1332622-47-5 4-oxo-1-(1-methyl-3-phenylpropyl)-N-(1-phenylethyl)-1,4-dihydroquinoline-3-carboxamide 
• 1332622-48-6 4-oxo-1-(1-methyl-3-phenylpropyl)-N-(2-methylphenyl)-1,4-dihydroquinoline-3-carboxamide 
• 311340-72-4 ethyl 3-(2-bromophenyl)-2-[(dimethylamino)methylene]-3-oxopropanoate 
• 135774-34-4 o-bromo-α-fluoroacetophenone 
• 1450828-30-4 3-(2-bromophenyl)-3-aminoacrylic acid ethyl ester 
• 62123-82-4 ethyl 2-(2-bromophenyl)-2-oxoacetate 

Relevant articles and documents

Synthesis of Dithiolethiones and Identification of Potential Neuroprotective Agents via Activation of Nrf2-Driven Antioxidant Enzymes

Oxidative stress is implicated in the pathogenesis of a wide variety of neurodegenerative disorders, and accordingly, dietary supplement of exogenous antioxidants or/and upregulation of the endogenous antioxidant defense system are promising for therapeutic intervention or chemoprevention of neurodegenerative diseases. Nrf2, a master regulator of the cellular antioxidant machinery, cardinally participates in the transcription of cytoprotective genes against oxidative/electrophilic stresses. Herein, we report the synthesis of 59 structurally diverse dithiolethiones and evaluation of their neuroprotection against 6-hydroxydopamine-or H2O2-induced oxidative damages in PC12 cells, a neuron-like rat pheochromocytoma cell line. Initial screening identified compounds 10 and 11 having low cytotoxicity but conferring remarkable protection on PC12 cells from oxidative-mediated damages. Further studies demonstrated that both compounds upregulated a battery of antioxidant genes as well as corresponding genes' products. Significantly, silence of Nrf2 expression abolishes cytoprotection of 10 and 11, indicating targeting Nrf2 activation is pivotal for their cellular functions. Taken together, the two lead compounds discovered here with potent neuroprotective functions against oxidative stress via Nrf2 activation merit further development as therapeutic or chemopreventive candidates for neurodegenerative disorders.

Palladium-Catalyzed Asymmetric Intramolecular Reductive Heck Desymmetrization of Cyclopentenes: Access to Chiral Bicyclo[3.2.1]octanes

A palladium-catalyzed asymmetric reductive Heck reaction of unactivated aliphatic alkenes, with eliminable β-hydrogen atoms, has been realized for the first time. A series of optically active bicyclo[3.2.1]octanes bearing chiral quaternary and tertiary carbon stereocenters were obtained in good yields with excellent enantioselectivities, exhibiting good functional-group tolerance and scalability. Moreover, deuterated optically active bicyclo[3.2.1]octanes were also obtained in high efficiency.

White mulberry root-bark active ingredient Morusin derivative and application and preparation method thereof

The invention discloses a Morusin derivative and a preparation method. A Morusin total-synthesis route is adopted to achieve a structure modification scheme, in the process of Morusin total synthesis, structure modification is carried out by replacing sub