62124-43-0

Usage

Uses

2-Chloro-5-phenyloxazole is a useful research chemical.

InChI:InChI=1/C9H6ClNO/c10-9-11-6-8(12-9)7-4-2-1-3-5-7/h1-6H

Upstream product

• 1006-68-4 5-phenyloxazole 
• 16172-23-9 5-phenyl-3H-oxazole-2-thione 
• 98-88-4 benzoyl chloride 
• 5468-37-1 2-aminoacetophenone hydrochloride 
• 16172-23-9 5-phenyl-1,3-oxazole-2-thiol 
• 129053-63-0 1-benzoyl-3-chloro-1,2,4-triazole 

Downstream Products

• 135307-33-4 N,5-diphenyloxazol-2-amine 
• 122320-86-9 2-[Methyl-(5-phenyl-oxazol-2-yl)-amino]-ethanol 

Relevant academic research and scientific papers

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

DIAMINOCYCLOHEXANE COMPOUNDS AND USES THEREOF

The present invention provides compounds of Formula (I), or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are agonists, partial agonists and modulators of the NPY Y4 rece

Arylpiperaszine derivatives, to the process for the production thereof and to the use thereof as therapeutic agents

The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent.

Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors

A series of derivatives of 2-anilino-5-phenyloxazole (5) has been identified as inhibitors of VEGFR2 kinase. Herein we describe the structure-activity relationship (SAR) of this novel template. Optimization of both aryl rings led to very potent inhibitors at both the enzymatic and cellular levels. Oxazole 39 had excellent solubility and good oral PK when dosed as the bis-mesylate salt and demonstrated moderate in vivo efficacy against HT29 human colon tumor xenografts. X-ray crystallography confirmed the proposed binding mode, and comparison of oxazoles 39 and 46 revealed interesting differences in orientation of 2-pyridyl and 3-pyridyl rings, respectively, attached at the meta position of the 5-phenyl ring.

A two-stage iterative process for the synthesis of poly-oxazoles

(Chemical Equation Presented) Methodology has been developed to prepare bis-oxazoles via a two-stage iterative process. The sequence begins with C 2-chlorination of a lithiated oxazole using hexachloroethane. Generation of the C2-Cs

SPECTROMETRIE DE MASSE DE TRIAZOLIDES ET DE LEURS PRODUITS DE TRANSFORMATION PAR PYROLYSE-ECLAIR SOUS VIDE

Besides the formation of acylium ions, the molecular ions of 1-acyl-1,2,4-triazoles substituted (R) at position 3 lose competitively ketene and carbon monoxide after electron impact ionization, but the ketene loss dominates largely if R is a strong electr

2-Sulfinyl and 2-sulfonyl oxazoles

Oxazoles having a sulfinyl or sulfonyl substituent at the 2-position are provided. Such compounds readily react with an alkali metal salt of a secondary amide in a method of making 2-acylamino oxazole derivatives having anti-allergic activity.