16172-23-9Relevant articles and documents
A convenient synthesis of 2-mercapto-oxazoles via β-ketoazide and its application to a key intermediate of PI3Kγ inhibitors
Oka, Yusuke,Yabuuchi, Tetsuya,Sekiguchi, Yoshinori
, p. 1881 - 1887 (2013/10/22)
A convenient synthesis of 2-mercapto-oxazoles via the reaction of β-ketoazide with triphenylphosphine (TPP) and carbon disulfide and its application to the synthesis of a key intermediate of phosphoinositide 3-kinase γ (PI3Kγ) inhibitors are described. The Japan Institute of Heterocyclic Chemistry.
Chloro(phenylthio)methyltrimethylsilane: Preparation and some Synthetic Reactions
Yamamoto, Iwao,Okuda, Kazuhide,Nagai, Shigemasa,Motoyoshiya, Jiro,Gotoh, Haruo,Matsuzaki, Kei
, p. 435 - 438 (2007/10/02)
Reaction of the title compound (2) with lead thiocyanate gave phenylthio(trimethylsilyl)methyl isothiocyanate (3) which further reacted with aromatic aldehydes in the presence of fluoride ion to afford oxazoles in good yields.Compound (2) also reacted with silyl enol ethers to give β-silyl ketones which were capable of being converted into β-functionalized vinylsilanes.
