6214-46-6

Basic information

• Product Name: ETHYL2-(4-HYDROXYPYRIMIDIN-5-YL)ACETATE
• Synonyms: ETHYL2-(4-HYDROXYPYRIMIDIN-5-YL)ACETATE;4-Hydroxy-5-pyrimidineacetic acid ethyl ester;ethyl 2-(6-oxo-1,6-dihydropyriMidin-5-yl)acetate;2-(6-oxo-1H-pyrimidin-5-yl)acetic acid ethyl ester;5-Pyrimidineaceticacid, 3,4-dihydro-4-oxo-, ethyl ester
• CAS NO: 6214-46-6
• Molecular Formula: C₈H₁₀N₂O₃
• Molecular Weight: 182.1766
• EINECS: 604-604-1
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 6214-46-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 155-156 °C
• Boiling Point: 314.46 °C at 760 mmHg
• Flash Point: 143.981 °C
• Appearance: /
• Density: 1.268 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.538
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.62±0.40(Predicted)
• CAS DataBase Reference: ETHYL2-(4-HYDROXYPYRIMIDIN-5-YL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL2-(4-HYDROXYPYRIMIDIN-5-YL)ACETATE(6214-46-6)
• EPA Substance Registry System: ETHYL2-(4-HYDROXYPYRIMIDIN-5-YL)ACETATE(6214-46-6)

Safety Data

• Hazardous Substances Data: 6214-46-6(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(4-hydroxypyrimidin-5-yl)acetate is a chemical compound that belongs to the class of pyrimidine derivatives. It is a colorless liquid that is commonly used in pharmaceutical and agrochemical industries. This chemical is known for its potential biological activities and is often used as a building block in organic synthesis to produce various pharmaceutical compounds. Its structure contains a pyrimidine ring with a hydroxyl group attached to the fifth position, and an ethyl acetate moiety attached to the second position of the pyrimidine ring. Due to its pharmacological properties, ethyl 2-(4-hydroxypyrimidin-5-yl)acetate has implications in the development of new drugs and agrochemical products.

InChI:InChI=1/C8H10N2O3/c1-2-13-7(11)3-6-4-9-5-10-8(6)12/h4-5H,2-3H2,1H3,(H,9,10,12)

Upstream product

• 29571-39-9 ethyl 2-(4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetate 
• 5472-38-8 diethyl 2-formylbutanedioate 
• 123-25-1 succinic acid diethyl ester 
• 3473-63-0 formamidine acetic acid 

Downstream Products

• 1393901-58-0 tert-butyl 4-(4-((4-((5-(2-ethoxy-2-oxoethyl)pyrimidin-4-yl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393901-59-1 tert-butyl 4-(4-((4-(2-(5-(2-ethoxy-2-oxoethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393901-60-4 lithium 2-(4-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetate 
• 1393901-61-5 tert-butyl 4-(4-((4-(2-(5-(2-amino-2-oxoethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393900-67-8 2-(4-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetamide 
• 1393900-68-9 2-(4-(2-(2-((4-(1-methylpiperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetamide 
• 5817-96-9 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one 

Relevant articles and documents

Convenient synthesis of 2-substituted 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones

A new synthetic route was elaborated at our laboratory providing a convenient access to 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones (diazaoxindoles), a compound family of biological relevance. Treatment of the easily available ethyl 2-(4-chloropyrimidin-5-yl)acetate derivatives with ammonia afforded the corresponding 2-(4-aminopyrimidin-5-yl)acetamides, which were finally cyclized to the target compounds.

FAK INHIBITORS

A compound of the formula (I): where R1 or R2 is a cycle amine group and R5 is an aromatic group with a carbonyl containing substituent for use as a FAK inhibitor.