29571-39-9

Basic information

• Product Name: ethyl 2-(4-hydroxy-2-mercaptopyrimidin-5-yl)acetate
• Synonyms: ethyl 2-(4-hydroxy-2-mercaptopyrimidin-5-yl)acetate;4-Hydroxy-2-mercapto-5-pyrimidineacetic acid ethyl ester;NSC 123141;(4-Hydroxy-2-Mercapto-pyriMidin-5-yl)-acetic acid ethyl ester;ethyl 2-(4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetate
• CAS NO: 29571-39-9
• Molecular Formula: C₈H₁₀N₂O₃S
• Molecular Weight: 214
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 29571-39-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 179-180℃
• Appearance: /
• Density: 1.36
• Refractive Index: 1.592
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ethyl 2-(4-hydroxy-2-mercaptopyrimidin-5-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-hydroxy-2-mercaptopyrimidin-5-yl)acetate(29571-39-9)
• EPA Substance Registry System: ethyl 2-(4-hydroxy-2-mercaptopyrimidin-5-yl)acetate(29571-39-9)

Safety Data

• Hazardous Substances Data: 29571-39-9(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(4-hydroxy-2-mercaptopyrimidin-5-yl)acetate is a chemical compound with the molecular formula C9H10N2O3S. It is a derivative of pyrimidine and contains a hydroxy and mercapto group on the pyrimidine ring. ethyl 2-(4-hydroxy-2-mercaptopyrimidin-5-yl)acetate is commonly used in organic synthesis and pharmaceutical research for its potential medicinal properties. It may also be used as a building block for the production of novel pharmaceuticals and agrochemicals. However, it should be handled and used with caution due to its potential reactivity and toxicity.

InChI:InChI=1/C8H10N2O3S/c1-2-13-6(11)3-5-4-9-8(14)10-7(5)12/h4H,2-3H2,1H3,(H2,9,10,12,14)

Upstream product

• 17356-08-0 thiourea 
• 5472-38-8 diethyl 2-formylbutanedioate 
• 58026-12-3 dimethyl formylsuccinate 
• 123-25-1 succinic acid diethyl ester 

Downstream Products

• 1393900-68-9 2-(4-(2-(2-((4-(1-methylpiperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetamide 
• 1393900-67-8 2-(4-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetamide 
• 1393901-61-5 tert-butyl 4-(4-((4-(2-(5-(2-amino-2-oxoethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393901-60-4 lithium 2-(4-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetate 
• 1393901-59-1 tert-butyl 4-(4-((4-(2-(5-(2-ethoxy-2-oxoethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393901-58-0 tert-butyl 4-(4-((4-((5-(2-ethoxy-2-oxoethyl)pyrimidin-4-yl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 6214-46-6 ethyl 2-(6-oxo-1,6-dihydropyrimidin-5-yl)acetate 
• 20763-91-1 uracil-5-ylacetic acid 

Relevant articles and documents

FAK AND FLT3 INHIBITORS

The use of a compound of the formula (I): (Formula (I)) in the preparation of a medicament for treating Acute Myeloid Leukemia or a disease ameliorated by the inhibition of Flt3, or Flt3 and FAK.

Linked peptide nucleic acids

Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to the peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.