29571-39-9

Usage

Uses

Used in Organic Synthesis:
Ethyl 2-(4-hydroxy-2-mercaptopyrimidin-5-yl)acetate is used as a key intermediate in organic synthesis for the preparation of various chemical compounds. Its unique structure and functional groups make it a valuable building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, ethyl 2-(4-hydroxy-2-mercaptopyrimidin-5-yl)acetate is used as a starting material for the development of new drugs. Its potential medicinal properties, such as its ability to interact with biological targets, make it a promising candidate for drug discovery and design.
Used in Agrochemical Development:
Ethyl 2-(4-hydroxy-2-mercaptopyrimidin-5-yl)acetate is also utilized in the agrochemical sector for the synthesis of novel agrochemicals. Its unique chemical structure and reactivity can be harnessed to create new compounds with potential applications in agriculture, such as pesticides or herbicides.

InChI:InChI=1/C8H10N2O3S/c1-2-13-6(11)3-5-4-9-8(14)10-7(5)12/h4H,2-3H2,1H3,(H2,9,10,12,14)

Upstream product

• 17356-08-0 thiourea 
• 5472-38-8 diethyl 2-formylbutanedioate 
• 123-25-1 succinic acid diethyl ester 
• 58026-12-3 dimethyl formylsuccinate 

Downstream Products

• 1393900-68-9 2-(4-(2-(2-((4-(1-methylpiperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetamide 
• 1393900-67-8 2-(4-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetamide 
• 1393901-61-5 tert-butyl 4-(4-((4-(2-(5-(2-amino-2-oxoethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393901-60-4 lithium 2-(4-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetate 
• 1393901-59-1 tert-butyl 4-(4-((4-(2-(5-(2-ethoxy-2-oxoethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393901-58-0 tert-butyl 4-(4-((4-((5-(2-ethoxy-2-oxoethyl)pyrimidin-4-yl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 6214-46-6 ethyl 2-(6-oxo-1,6-dihydropyrimidin-5-yl)acetate 
• 20763-91-1 uracil-5-ylacetic acid 

Relevant academic research and scientific papers

FAK AND FLT3 INHIBITORS

The use of a compound of the formula (I): (Formula (I)) in the preparation of a medicament for treating Acute Myeloid Leukemia or a disease ameliorated by the inhibition of Flt3, or Flt3 and FAK.

FAK INHIBITORS

A compound of the formula (I): where R1 or R2 is a cycle amine group and R5 is an aromatic group with a carbonyl containing substituent for use as a FAK inhibitor.

Linked peptide nucleic acids

Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to the peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.

Peptide nucleic acids

Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be orientated either parallel or antiparallel to each other.