62146-59-2Relevant academic research and scientific papers
Structure-activity relationship study on a simple cationic peptide motif for cellular delivery of antisense peptide nucleic acid
Albertshofer, Klaus,Siwkowski, Andrew M.,Wancewicz, Edward V.,Esau, Christine C.,Watanabe, Tanya,Nishihara, Kenji C.,Kinberger, Garth A.,Malik, Leila,Eldrup, Anne B.,Manoharan, Muthiah,Geary, Richard S.,Monia, Brett P.,Swayze, Eric E.,Griffey, Richard H.,Bennett, C. Frank,Maier, Martin A.
, p. 6741 - 6749 (2005)
Improving cellular uptake and biodistribution remains one of the major obstacles for a successful and broad application of peptide nucleic acids (PNAs) as antisense therapeutics. Recently, we reported the identification and functional characterization of
PEPTOID-BASED CHELATING LIGANDS FOR SELECTIVE METAL CHELATION
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Paragraph 0081-0082, (2020/04/29)
The present disclosure provides peptoid-based chelating ligands, corresponding cyclic peptoids, and methods of making thereof. Functional groups may be tailored for high metal binding affinity and selectivity. The side chains of a cyclic peptoid according to the present disclosure may be selected based on, for example, high affinity for actinide or other metal ions, selectivity for actinide or other metal ions, the ability to recover a metal once it is bound to the peptoid, and whether the overall peptoid should be hydrophobic or hydrophilic. Unlike siderophores, peptoid-based chelating ligands of the present disclosure are not readily hydrolyzed under physiological conditions. Therefore, peptoid-based chelating ligands may be, for example, used to treat actinide (e.g., iron and lead) poisoning in vivo. Moreover, peptoid-based chelating ligands of the present disclosure may be used for medical imaging, chelation therapy, drug delivery, and separation technologies, for example.
Degradable PEG-folate coated poly(DMAEA-co-BA)phosphazene-based polyplexes exhibit receptor-specific gene expression
Luten,van Steenbergen,Lok,de Graaff,van Nostrum,Talsma,Hennink
, p. 241 - 251 (2008/04/01)
A new cationic biodegradable polyphosphazene was developed, bearing both pendant primary and tertiary amine side groups, poly(2-dimethylaminoethylamine-co-diaminobutane)phosphazene (poly(DMAEA-co-BA)phosphazene). PEG and PEG-folate were coupled to polyple
Synthesis of Carbamate Protected Spermidine Homologues Through α,ω-Alkanediamines
Arasujo, M. Joso S. M. P.,Ragnarsson, Ulf,Trigo, M. Joaquina S. A. Amaral,Almeida, M. Lurdes S.
, p. 2143 - 2161 (2007/10/03)
The total synthesis of three triamines selectively protected in the primary amino groups (1a-c) and two triamines protected in the secondary amino function and in one of the primary amino functions (2a and 2c), based on a simple and efficient procedure, is described.
Practical, convergent total synthesis of polyamine amide spider toxin NSTX-3
Blagbrough, Ian S.,Moya, Eduardo,Walford, Steven P.
, p. 551 - 554 (2007/10/02)
A practical, total synthesis of polyamine amide spider toxin NSTX-3, a potent glutamate receptor antagonist with potential as a neuroprotective agent, is reported. The unsymmetrical polyamine moiety was built by a conjugate addition to afford putreanine and regioselective acylation of L-asparaginyl-cadaverine.
