33545-98-1

Usage

Chemical Properties

White crystalline powder

InChI:InChI=1/C9H20N2O2.ClH/c1-9(2,3)13-8(12)11-7-5-4-6-10;/h4-7,10H2,1-3H3,(H,11,12);1H

Upstream product

• 68076-36-8 1-amino-4-[(tert-butyloxycarbonyl)amino]butane 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13325-10-5 4-Aminobutanol 
• 174626-25-6 methanesulfonic acid 4-tert-butoxycarbonylaminobutyl ester 
• 75178-87-9 (4-hydroxybutyl)carbamic acid tert-butyl ester 
• 129392-85-4 N-t-butoxycarbonyl-4-azidobutylamine 

Downstream Products

• 62146-59-2 Z-NH-(CH₂)4-NH-Boc 
• 142230-53-3 N⁽¹⁾-p-nitrobenzoyl-N⁽⁴⁾-(tert-butyloxycarbonyl)-1,4-diaminobutane 
• 788825-29-6 C₂₂H₂₈N₂O₄ 
• 260433-14-5 N⁽¹⁾-Boc-N⁽⁴⁾-benzoyl-1,4-diaminobutane 
• 1335096-55-3 N⁽¹⁾-Boc-N⁽⁴⁾-benzenesulfonyl-1,4-diaminobutane 
• 129392-85-4 N-t-butoxycarbonyl-4-azidobutylamine 

Relevant academic research and scientific papers

NOVEL PEPTIDE DERIVATIVES FOR TREATMENT, PREVENTION OR ALLEVIATION OF A CONDITION ASSOCIATED WITH BONE LOSS OR LOW BONE DENSITY OR TO INHIBIT OSTEOCLAST DIFFERENTIATION AND STIMULATION

Novel compounds which may be for treatment, prevention or alleviation of a condition associated with bone loss or low bone density or to inhibit osteoclast differentiation and stimulation, bone resorption, or loosening of a prosthetic device.

An efficient and practical method for the synthesis of mono-N-protected α,ω-diaminoalkanes

The large-scale synthesis of mono-N-protected (Cbz, Boc, Ts, and Ns) α,ω-diaminoalkanes (the number of carbon atoms=3, 4, 5 and 6) are accomplished in 81-94% yield by the protection of amine and subsequent reduction of an azido group from α,ω-azido alkyl amines. α,ω-Azido alkyl amines are prepared efficiently by the partial reduction of α,ω-diazidoalkanes which are obtained from the corresponding dibromoalkanes.

Mono-Protected Diamines. Nα-tert-Butoxycarbonyl α,ω-Alkanediamine Hydrochlorides from Amino alcohols.

Nα-tert-Butoxycarbonyl α,ω-alkanediamine hydrochlorides 3a-e are prepared from the amino alcohols in yields of 66-87percent.Reaction of the free amine with di-tert-butyl dicarbonate gives the N-tert-Butoxycarbonylamino alcohol 1a-e.One-pot conversion to the azide 2a-e via the mesylate under phase-transfer conditions followed by hydrogenolysis in the presence of chloroform yields the title compounds.