6217-68-1

Usage

Uses

Used in Organic Synthesis:
P-NITROPHENYL SULFATE POTASSIUM SALT is used as a reagent in organic synthesis for its ability to facilitate chemical reactions and produce desired products.
Used in Enzyme Assays:
P-NITROPHENYL SULFATE POTASSIUM SALT is used as a substrate for p-nitrophenyl glycoside-based enzyme assays, allowing researchers to measure the activity of specific enzymes, such as arylsulfatase, in cell-free coelomic fluid.
Used in Enzyme Inhibition:
P-NITROPHENYL SULFATE POTASSIUM SALT is used as an inhibitor for arylsulfatase, providing a means to study the effects of enzyme inhibition on various biological processes and potential therapeutic applications.
Used as an Inorganic Analog:
P-NITROPHENYL SULFATE POTASSIUM SALT is used as an inorganic analog of organic aryl ester sulfate, offering a comparative study of the properties and reactivity of these compounds in different chemical contexts.

InChI:InChI=1/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)/p-1

Upstream product

• 1080-04-2 p-nitrophenyl sulfate 
• 100-02-7 4-nitro-phenol 
• 75-15-0 carbon disulfide 

Downstream Products

• 63975-21-3 N-hydroxy-N-(4-hydroxyphenyl)acetamide 
• 100-02-7 4-nitro-phenol 

Relevant academic research and scientific papers

METHOD FOR PRODUCING P-NITROPHENYL SULFATE

PROBLEM TO BE SOLVED: To provide a method for producing a p-nitrophenyl sulfate (PNPS salt) such as potassium p-nitrophenyl sulfate (PNPS-K). SOLUTION: A p-nitrophenyl sulfate is produced by reacting p-nitrophenol (PNP) with sulfur trioxide complex in a medium having a low capacity of dissolving p-nitrophenyl sulfate such as tetrahydrofuran, and neutralizing the reaction product with tert-butoxy salt. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

Ground state structures of sulfate monoesters and sulfamates reveal similar reaction coordinates for sulfuryl and sulfamyl transfer

Structure/reactivity and structure/structure correlations of 5 sulfate monoesters and 11 sulfamate esters determined by low temperature X-ray crystallography reveal similar ground state deformations that suggest similar reaction coordinates for sulfuryl and sulfamyl group transfer. The Royal Society of Chemistry 2006.

34S Isotope Effect on Sulfate Ester Hydrolysis: Mechanistic Implications

In this communication, we report the first determination of 34S kinetic isotope effects (KIEs) for the hydrolysis of sulfate monoesters. The method involves the conversion of the inorganic sulfate, acquired at partial extent of reaction, to SO2, followed by isotope ratio determination by mass spectrometry. The KIEs determined for p-nitrophenyl sulfate and p-acetylphenyl sulfate are 1.0154 (±0.0002) and 1.0172 (±0.0003), respectively. These results, together with previous peripheral 18O KIE values, are inconsistent with an associative mechanism. The isotope effect method we report should also prove useful for studying the mechanism of other sulfuryl group transfers, including sulfatase and sulfotransferase reactions, as well as sulfate hydrolyses under other conditions. Copyright

The Synthesis of p-Nitrophenyl Sulphate

The procedure for the synthesis of p-nitrophenyl sulphate, a substrate for arylsulphatase activity estimation, has been described.