62221-40-3Relevant academic research and scientific papers
Studies towards the Total Synthesis of Drimentine C. Preparation of the AB and CDEF Ring Fragments
Pound, Sarah M.,Underwood, Steven J.,Douglas, Christopher J.
supporting information, p. 2448 - 2453 (2020/04/27)
The drimentine family is a class of hybrid isoprenoids derived from actinomycete bacteria. Members of this family display weak antitumor and antibacterial activity. Herein we report our efforts toward the total synthesis of drimentine C using three distinct approaches incorporating palladium-catalyzed cyanoamidation, reductive cross-coupling, and photoredox-catalyzed α-alkylation of an aldehyde as key steps. Our synthetic efforts use a convergent synthesis to assemble the terpenoid and alkaloid portions of drimentine C from readily available l-tryptophan, l-proline, and (+)-sclareolide.
Highly Selective Hydrogenation of Aromatic Ketones and Phenols Enabled by Cyclic (Amino)(alkyl)carbene Rhodium Complexes
Wei, Yu,Rao, Bin,Cong, Xuefeng,Zeng, Xiaoming
supporting information, p. 9250 - 9253 (2015/08/11)
Air-stable Rh complexes ligated by strongly σ-donating cyclic (amino)(alkyl)carbenes (CAACs) show unique catalytic activity for the selective hydrogenation of aromatic ketones and phenols by reducing the aryl groups. The use of CAAC ligands is essential for achieving high selectivity and conversion. This method is characterized by its good compatibility with unsaturated ketones, esters, carboxylic acids, amides, and amino acids and is scalable without detriment to its efficiency.
Nor-statine and nor-cyclostatine polypeptides
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, (2008/06/13)
Polypeptides and derivatives thereof containing nor-statine and nor-cyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.
Cyclopentanone Synthesis by Intramolecular Carbon-Hydrogen Insertion of Diazo Ketones. A Diterpene-to-Steroid Skeleton Conversion
Wenkert, Ernest,Davis, Linda L.,Mylari, Banavara L.,Solomon, Mary F.,Silva, Roberto R. da,et al.
, p. 3242 - 3247 (2007/10/02)
Intramolecular carbon-hydrogen insertion on cupric sulfate assisted decomposition of diazomethyl ketones derived from four 1-methylcycloalkanecarboxylic acids and (hexahydrophenyl)acetic, homopivalic, and enanthic acids is shown to yield mostly cyclopentanones.The yields are appreciable in the conformationally favorable cases, and insertion in the solvent cyclohexane can be avoided by the use of Freon TF as the solvent.The conversion of a primaradienic diterpene into a 14-iso-16-androstanone derivative shows the power of the new method of cyclopentanone synthesis.
FACILE HYDROGENATION OF AROMATIC NUCLEI WITH SODIUM BOROHYDRIDE-RHODIUM CHLORIDE IN HYDROXYLIC SOLVENTS
Nishiki, Mayumi,Miyataka, Hideki,Niino, Yasunori,Mitsuo, Naoki,Satoh, Toshio
, p. 193 - 196 (2007/10/02)
Sodium borohydride-rhodium chloride in hydroxylic solvent was proved to be very useful for the reduction of aromatic nuclei to the corresponding saturated cycles under mild conditions.
Alicyclic alkylene polyamine microorganism and algae growth inhibitors
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, (2008/06/13)
Novel dicyclohexyl, dicyclohexenyl and cyclohexylcyclohexenylalkyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful in agriculture to protect plants against diseases such as leaf, stem, and fruit spotting
Broad spectrum antibacterial compositions containing tris-(hydroxymethyl)-aminoethane and dicycloaliphatic-alkyl polyamines
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, (2008/06/13)
A composition comprising tris-(hydroxymethyl)aminomethane and dicyclohexyl-, dicyclohexenyl- and cyclohexylcyclohexenyl-alkyl polyamines, their acid addition salts, and mixtures thereof are useful as antibacterial agents. The composition is particularly u
