622369-69-1

Basic information

• Product Name: 7-fluoro-4-oxo-1,4-dihydroquinoline-3-carbonitrile
• Synonyms: 7-Fluor-4-hydroxychinolin-3-carbonitril; 7-Fluor-4-oxo-1,4-dihydrochinolin-3-carbonitril; 7-fluoro-4-hydroxyquinoline-3-carbonitrile
• CAS NO: 622369-69-1
• Molecular Formula: C₁₀H₅FN₂O
• Molecular Weight: 188.1579
• Mol File: 622369-69-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 300.603°C at 760 mmHg
• Flash Point: 135.6°C
• Density: 1.412g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: 7-fluoro-4-oxo-1,4-dihydroquinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 7-fluoro-4-oxo-1,4-dihydroquinoline-3-carbonitrile(622369-69-1)
• EPA Substance Registry System: 7-fluoro-4-oxo-1,4-dihydroquinoline-3-carbonitrile(622369-69-1)

Safety Data

• Hazardous Substances Data: 622369-69-1(Hazardous Substances Data)

Upstream product

• 622369-68-0 ethyl 2-{[(1E)-(dimethylamino)methylidene]amino}-4-fluorobenzoate 
• 75-05-8 acetonitrile 

Downstream Products

• 622369-70-4 4-chloro-7-fluoro-3-quinolinecarbonitrile 

Relevant articles and documents

Facile preparation of new 4-phenylamino-3-quinolinecarbonitrile Src kinase inhibitors via 7-fluoro intermediates: Identification of potent 7-amino analogs

A more efficient preparation of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile (2), the penultimate intermediate in the synthesis of bosutinib (1a), was developed. New 7-alkoxy-4-phenylamino-3-quinolinecarbonitrile Src