62257-15-2

Basic information

• Product Name: Benzenamine, 2-fluoro-5-methoxy- (9CI)
• Synonyms: Benzenamine, 2-fluoro-5-methoxy- (9CI);2-fluoro-5-methoxyaniline;3-Amino-4-fluoroanisole, 6-Fluoro-m-anisidine;2-Fluoro-5-Methoxy-phenylaMine;3-AMino-4-fluoroanisole[2-Fluoro-5-Methoxyaniline];BenzenaMine,2-fluoro-5-Methoxy-
• CAS NO: 62257-15-2
• Molecular Formula: C₇H₈FNO
• Molecular Weight: 141.1429232
• Product Categories: VARIOUSAMINE
• Mol File: 62257-15-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 237.581 °C at 760 mmHg
• Flash Point: 97.486 °C
• Appearance: /
• Density: 1.176
• Vapor Pressure: 0.044mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.78±0.10(Predicted)
• CAS DataBase Reference: Benzenamine, 2-fluoro-5-methoxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 2-fluoro-5-methoxy- (9CI)(62257-15-2)
• EPA Substance Registry System: Benzenamine, 2-fluoro-5-methoxy- (9CI)(62257-15-2)

Safety Data

• Hazardous Substances Data: 62257-15-2(Hazardous Substances Data)

Usage

General Description

Benzenamine, 2-fluoro-5-methoxy- (9CI), also known as 2-Fluoro-5-methoxyaniline, is a chemical compound with the molecular formula C7H8FNO. Benzenamine, 2-fluoro-5-methoxy- (9CI) belongs to the class of organic compounds known as anilines, which are characterized by their benzene ring joined to an amino group. It has a role as an environmental contaminant and is a member of methoxybenzenes. In terms of its physical properties, it is identified as a neutral compound and is typically stored in a cool, dry place in a tightly closed container. Due to its nature, it is recommended to avoid contact with skin and eyes, and one must exercise caution during its handling and disposal.

InChI:InChI=1/C7H8FNO/c1-10-5-2-3-6(8)7(9)4-5/h2-4H,9H2,1H3

Upstream product

• 346664-78-6 1,3-dibromo-5-fluoro-2-methoxy-4-nitro-benzene 
• 346664-90-2 N,N-diethyl-4-[[1(3-furanylmethyl)-4-piperidinyl](3-methoxyphenyl)amino]-benzamide 
• 400-92-0 2-fluoro-5-methoxybenzamide 
• 84478-76-2 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene 
• 62257-16-3 5-hydroxy-2-fluoroaniline 
• 77-78-1 dimethyl sulfate 
• 344-20-7 2,6-dibromo-4-fluorophenol 
• 443-41-4 1,3-dibromo-5-fluoro-2-methoxybenzene 
• 536-90-3 m-Anisidine 
• 26595-63-1 1-methoxy-3-nitrosobenzene 

Downstream Products

• 674336-49-3 N-(2-fluoro-5-methoxyphenyl)urea 

Relevant articles and documents

Anion ligand promoted selective C-F bond reductive elimination enables C(sp2)-H fluorination

A detailed mechanism study on the anion ligand promoted selective C-H bond fluorination is reported. The role of the anion ligand has been clarified by experimental evidence and DFT calculations. Moreover, the nitrate promoted C-F bond reductive elimination enabled a selective C-H bond fluorination of various symmetric and asymmetric azobenzenes to access diverse o-fluoroanilines.

Compound and application of compound in preparation of medicines

The invention discloses a compound and its application in a medicine. the invention specifically provides a compound as shown in the formula (I) or a stereisomer, a geometrical isomer, a tautomer, a racemate, nitric oxide, hydrate, a solvate, a metabolite, pharmaceutically acceptable salts or a prodrug of the compound as shown in the formula (I). The invention also discloses an application of the compound in preparation of a medicine. The medicine is used in treating cancers.

New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors

The invention relates to compounds of formula (I) wherein R1, R2 and m are as defined in the description, their use as medicament, pharmaceutical compositions containing them and a process for their preparation. These compounds act as Phosphodiesterase inhibitors and inhibit in particular PDE-7.