62259-92-1

Basic information

• Product Name: 7-Benzyl-2-Methyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyriMidin-4-one
• Synonyms: 7-Benzyl-2-Methyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyriMidin-4-one;Pyrido[3,4-d]pyrimidin-4(3H)-one, 5,6,7,8-tetrahydro-2-methyl-7-(phenylmethyl)-;7-benzyl-2-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one
• CAS NO: 62259-92-1
• Molecular Formula: C₁₅H₁₇N₃O
• Molecular Weight: 255.31498
• EINECS: -0
• Mol File: 62259-92-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 7-Benzyl-2-Methyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyriMidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Benzyl-2-Methyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyriMidin-4-one(62259-92-1)
• EPA Substance Registry System: 7-Benzyl-2-Methyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyriMidin-4-one(62259-92-1)

Safety Data

• Hazardous Substances Data: 62259-92-1(Hazardous Substances Data)

Upstream product

• 39514-19-7 ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate 
• 143-37-3 acetamidine 
• 124-42-5 acetamidine hydrochloride 
• 52763-21-0 ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride 

Downstream Products

• 1073477-08-3 2-methyl-4-oxo-4,5,6,8-tetrahydro-3H-pyrido[3,4-d]pyrimidine-7-carboxylic acid 4-bromophenyl ester 
• 62259-95-4 2-methyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one 
• 300552-41-4 7-benzyl-4-chloro-2-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine 

Relevant articles and documents

Inhibitors of HIV-1 attachment: The discovery and structure-activity relationships of tetrahydroisoquinolines as replacements for the piperazine benzamide in the 3-glyoxylyl 6-azaindole pharmacophore

6,6-Fused ring systems including tetrahydroisoquinolines and tetrahydropyrido[3,4-d]pyrimidines have been explored as possible replacements for the piperazine benzamide portion of the HIV-1 attachment inhibitor BMS-663068. In initial studies, the tetrahydroisoquinoline compounds demonstrate sub-nanomolar activity in a HIV-1 pseudotype viral infection assay used as the initial screen for inhibitory activity. Analysis of SARs and approaches to optimization for an improved drug-like profile are examined herein.

PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to Pyrimidinone Derivatives, compositions comprising a Pyrimidinone Derivative, and methods of using the Pyrimidinone Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of G protein-coupled receptor 119 ("GPR119") in a patient.