7-Benzyl-2-Methyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyriMidin-4-one

Base Information

• Chemical Name: 7-Benzyl-2-Methyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyriMidin-4-one
• CAS No.: 62259-92-1
• Molecular Formula: C15H17N3O
• Molecular Weight: 255.319
• Mol file: 62259-92-1.mol

Synonyms:7-BENZYL-2-METHYL-5,6,7,8-TETRAHYDRO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE;

Chemical Property of 7-Benzyl-2-Methyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyriMidin-4-one

Chemical Property:

• PSA: 49.25000
• LogP: 1.98680
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

7-Benzyl-2-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Benzyl-2-Methyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyriMidin-4-one

There total 3 articles about 7-Benzyl-2-Methyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyriMidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

acetamidine hydrochloride (124-42-5) + ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride (52763-21-0) → 7-benzyl-2-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one (62259-92-1)

Guidance literature:

With sodium methylate; In methanol; at 25 ℃; for 20h; Inert atmosphere;

DOI:10.1016/j.bmcl.2015.11.009

Reference yield:

ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate (39514-19-7) + acetamidine (143-37-3) → 7-benzyl-2-methyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one (62259-92-1)

Guidance literature:

With sodium ethanolate; In ethanol; Reflux;

DOI:10.1016/j.bmcl.2010.09.023

Reference yield:

→ 7-benzyl-2-methyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one (62259-92-1)

Guidance literature:

N-Benzyl-4-carboethoxy-3-piperidon-Hydrochlorid, entspr. Amidin, NaOEt/EtOH;

upstream raw materials:

ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate

acetamidine

acetamidine hydrochloride

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

Downstream raw materials:

2-methyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one

7-benzyl-4-chloro-2-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

2-methyl-4-oxo-4,5,6,8-tetrahydro-3H-pyrido[3,4-d]pyrimidine-7-carboxylic acid 4-bromophenyl ester

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