62261-35-2

Upstream product

• 54118-78-4 4'-methoxy-3-nitro-benzophenone 
• 626-01-7 3-Iodoaniline 
• 100-07-2 4-methoxy-benzoyl chloride 
• 121-90-4 m-nitrobenzoic acid chloride 
• 100-66-3 methoxybenzene 

Downstream Products

• 90231-96-2 3-<(dimethylsulfamoyl)amino>-4'-methoxybenzophenone 
• 99641-92-6 Propane-2-sulfonic acid {3-[[(E)-hydroxyimino]-(4-methoxy-phenyl)-methyl]-phenyl}-amide 
• 99641-90-4 anti-3-<(dimethylsulfamoyl)amino>-4'-methoxybenzophenone oxime 
• 99641-91-5 Pyrrolidine-1-sulfonic acid {3-[[(E)-hydroxyimino]-(4-methoxy-phenyl)-methyl]-phenyl}-amide 
• 22731-30-2 4-CH₃OC₆H₄C(O)C₆H₄NHSO₂CF₃ 
• 1220496-85-4 [3-(benzylideneamino)phenyl]-(4-methoxyphenyl)methanone 
• 1220496-87-6 {3-[(4-methoxybenzylidene)amino]phenyl}-(4-methoxyphenyl)methanone 

Relevant academic research and scientific papers

Direct preparation of new organozinc reagents, aminophenylzinc iodides, and their applications

New organozinc reagents, 4-aminophenyl zinc iodide (A) and 3-aminophenyl zinc iodide (B), have been generated easily and effectively by the direct insertion of active zinc to iodoanilines which possess acidic protons. The subsequent coupling reactions of the organozincs with various acid chlorides turned out to be an efficient tool for the preparation of aminophenyl ketones.

Utility of Complementary Molecular Reactivity and Molecular Recognition (CMR/R) Technology and Polymer-Supported Reagents in the Solution-Phase Synthesis of Heterocyclic Carboxamides

The use of our recently reported chemical library purification strategy in the development of a herbicidal lead, N-(3-benzoylphenyl)-3-(1,1-dimethylethyl)-1-methyl-1H-pyrazole-5-carboxamide (3), is described. The approach applying fundamental properties of complementary molecular reactivity and molecular recognition (CMR/R) as the basis for a general purification strategy was utilized. Polymeric reagents were used in the synthesis to generate reactive species involved in product formation, and complementary molecular reactivity/molecular recognition polymer 8 (CMR/R polymer 8) was used in the solution-phase syntheses of building blocks, primary libraries, and lead refinement libraries. An extension of the CMR/R methodology was applied, utilizing a sequestration enabling reagent (SER), transforming a reactant into an electrophilic species sequestrable by CMR/R polymer 8. This library purification strategy enabled rapid lead generation and lead refinement to afford herbicide 27o. The CMR/R solid-phase purification technique enabled a simple, general, and powerful protocol, eliminating the usual tedious and time-consuming methods required for solution-phase product purification. The result was the synthesis of hundreds of compounds, prepared in a relatively short time, leading to a compound with a 4-fold improvement in herbicidal activity over the initial lead.