62265-91-2

Upstream product

• 1260150-42-2 C₁₈H₁₇NO₂ 
• 536-74-3 phenylacetylene 
• 14963-94-1 7-methoxy-3-phenyl-1H-isochromen-1-one 
• 35450-36-3 methyl 2-bromo-5-methoxybenzoate 
• 99848-43-8 2-bromo-5-methoxybenzamide 
• 98-86-2 acetophenone 

Downstream Products

• 181371-83-5 7-Methoxy-4-nitro-3-phenyl-2H-isoquinolin-1-one 
• 181371-87-9 ICC₁08-L-006-H₀₃- 
• 181372-03-2 (7-Methoxy-3-phenyl-isoquinolin-4-yl)-carbamic acid ethyl ester 
• 181372-14-5 N-(7-Methoxy-1-oxo-3-phenyl-1,2-dihydro-isoquinolin-4-yl)-acetamide 
• 181372-00-9 (1-Chloro-7-methoxy-3-phenyl-isoquinolin-4-yl)-carbamic acid ethyl ester 
• 181371-91-5 (7-Methoxy-1-oxo-3-phenyl-1,2-dihydro-isoquinolin-4-yl)-carbamic acid ethyl ester 

Relevant academic research and scientific papers

Triflic acid mediated sequential cyclization of ortho-alkynylarylesters with ammonium acetate

A triflic acid (TfOH) mediated sequential cyclization of ortho-alkynylarylesters and ammonium acetate (NH4OAc) was reported. The reaction took place via a Br?nsted acid-mediated intramolecular cyclization of ortho-alkynylarylesters followed by an ammonium acetate participated substitution reaction, forming isoquinolin-1-ones as the major products. Different from most of the known synthetic methods of isoquinolin-1-ones, no metal catalyst was required in the reported reaction. The regioisomers – isoindolin-1-ones were obtained together with isoquinolin-1-ones in a few cases. The intermediate compounds – isochromen-1-ones and isobenzofuran-1-ones were also isolated. The interconversion experiments showed that the regioisomers formed during the Br?nsted acid induced intramolecular cyclization of ortho-alkynylarylesters. A natural product – ruprechstyril was prepared in a moderate yield employing the new method.

Synthesis of functionalized isoquinolin-1(2H)-ones by copper-catalyzed α-arylation of ketones with 2-halobenzamides

Copper is key: A concise route to isoquinolin-1(2H)-ones from simple and readily available starting materials is provided by an efficient copper-catalyzed annulation of ketones with 2-halobenzamides. The method is applicable to a wide range of ketones con

Platinum(II)-catalyzed intramolecular cyclization of alkynylbenzonitriles: Synthesis of 1-alkoxyisoquinolines and isoquinolones

A facile synthesis of a series of 1-alkoxyisoquinolines and (2H)-isoquinolones by an intramolecular 6-endo-dig cyclization of ortho-alkynylbenzonitriles in the presence of a catalytic amount of hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito- κP)]platinum(II) in various alcohols at 65-90 °C is described for the first time.

A convenient way to dibenzo[c,h]-1,5-naphthyridines (11-aza-benzo[c] phenanthridines)

Whereas thermal cyclisation of variously substituted 2,3-diarylacrylazides easily provided a new way to 3-aryl-isoquinolones, nitration of these compounds mainly led to corresponding 3-aryl-4-nitro-isoquinolones. After reduction into 4-amino-3-aryl-isoquinolones, amidification and subsequent cyclization gave the yet unknown title compounds.