62283-07-2

Basic information

• Product Name: Acetyl azide, phenoxy-
• CAS NO: 62283-07-2
• Molecular Formula: C8H7N3O2
• Molecular Weight: 177.162
• Mol File: 62283-07-2.mol

Chemical Properties

• CAS DataBase Reference: Acetyl azide, phenoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetyl azide, phenoxy-(62283-07-2)
• EPA Substance Registry System: Acetyl azide, phenoxy-(62283-07-2)

Safety Data

• Hazardous Substances Data: 62283-07-2(Hazardous Substances Data)

Upstream product

• 701-99-5 Phenoxyacetyl chloride 
• 122-59-8 2-phenoxyacetic acid 
• 108-95-2 phenol 

Downstream Products

• 1610785-11-9 1-((4-amino-2-methylpyrimidin-5-yl)methyl)-3-(phenoxymethyl)urea 

Relevant articles and documents

Design, synthesis and molecular docking of amide and urea derivatives as Escherichia coli PDHc-E1 inhibitors

By targeting the ThDP binding site of Escherichia coli PDHc-E1, two new 'open-chain' classes of E. coli PDHc-E1 inhibitors, amide and urea derivatives, were designed, synthesized, and evaluated. The amide derivatives of compound 6d, with 4-NO2 in the benzene ring, showed the most potent inhibition of E. coli PDHc-E1. The urea derivatives displayed more potent inhibitory activity than the corresponding amide derivatives with the same substituent. Molecular docking studies confirmed that the urea derivatives have more potency due to the two hydrogen bonds formed by two NH of urea with Glu522. The docking results also indicate it might help us to design more efficient PDHc-E1 inhibitors that could interact with Glu522.

Direct synthesis of acyl azides from carboxylic acids by the combination of trichloroacetonitrile, triphenylphosphine and sodium azide

Various carboxylic acids were converted into acyl azides in excellent yields by treating with trichloroacetonitrile, triphenylphosphine and sodium azide at room temperature. The reaction was applicable to the preparation of dipeptide without rearrangement.

3,4,5-Trifluorobenzeneboronic acid: A mild and versatile catalyst for the one-pot synthesis of acyl azides from carboxylic acids

Acyloxyboron intermediates generated from carboxylic acids and 3,4,5-trifluorobenzeneboronic acid react with sodium azide to furnish the corresponding acyl azides in moderate to good yields.

A mild and efficient method for the preparation of acyl azides from carboxylic acids using triphosgene

An efficient use of triphosgene for the preparation of various acyl azides from carboxylic acids and sodium azide is described.

Kinetics of the Decomposition of Aliphatic Acyl Azides

The kinetics of the decomposition of a series of aliphatic acyl azides have been investigated.The first-order rate constants and activation parameters have been determined and the influence of the substituents and of solvent polarity on the rate of decomposition has been established.