62298-35-5Relevant academic research and scientific papers
Regioselective Syntheses of the Indolopyridine Alkaloids Nauclefine, Angustine, Dihydroangustine and Naucletine from a Common Intermediate
Lavilla, Rodolfo,Gullon, Francisco,Bosch, Joan
, p. 1675 - 1676 (1995)
A short, flexible route for the synthesis of the title indolopyridine alkaloids consisting of the cyclization of enamide 3, followed by introduction of the requisite pyridine substituent by Pd0-catalysed reactions from the resulting pentacyclic bromo intermediate 4 is reported.
A unified synthetic strategy for the indolopyridine alkaloid group
Lavilla, Rodolfo,Gullón, Francisco,Bosch, Joan
, p. 373 - 378 (2007/10/03)
Thermal or acetyl chloride induced cyclization of bromoenamide 10 affords the pentacyclic derivative 12 with high yield and regioselectivity. From this common synthetic intermediate, palladium-catalyzed reactions allow the total synthesis of indolopyridin
