623-69-8

Usage

Uses

1. Used in the Fuel Industry:
1,3-Dimethoxy-2-propanol is used as an antiknock additive for gasoline and diesel fuel. Its addition to fuel helps to increase the octane rating, reducing engine knocking and improving the overall performance of the engine. This application is particularly useful in the automotive and transportation sectors, where fuel efficiency and engine performance are crucial.
2. Used in the Pharmaceutical Industry:
1,3-Dimethoxy-2-propanol is used to prepare heteroarylcarbamoylbenzene derivatives, which act as glucokinase activators. These derivatives have potential applications in the treatment of type 2 diabetes and other metabolic disorders. By activating glucokinase, they help regulate blood glucose levels and improve insulin sensitivity, offering a promising therapeutic approach for managing diabetes and related conditions.

InChI:InChI=1/C5H12O3/c1-7-3-5(6)4-8-2/h5-6H,3-4H2,1-2H3

Upstream product

• 56-81-5 glycerol 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 74-88-4 methyl iodide 

Downstream Products

• 34680-57-4 2-Chlor-1,3-dimethoxy-propane 
• 18664-32-9 1,3-dimethoxypropan-2-one 
• 28248-53-5 Thiophosphoric acid O-(2-methoxy-1-methoxymethyl-ethyl) ester O'-methyl ester O''-(4-methylsulfanyl-phenyl) ester 
• 28248-65-9 Thiophosphoric acid O-ethyl ester O'-(2-methoxy-1-methoxymethyl-ethyl) ester O''-(4-methylsulfanyl-phenyl) ester 
• 28383-08-6 Thiophosphoric acid O-(4-methanesulfinyl-phenyl) ester O'-(2-methoxy-1-methoxymethyl-ethyl) ester O''-methyl ester 
• 28372-32-9 Thiophosphoric acid O-(2-methoxy-1-methoxymethyl-ethyl) ester O'-methyl ester O''-(4-nitro-phenyl) ester 
• 28383-09-7 Thiophosphoric acid O-ethyl ester O'-(4-methanesulfinyl-phenyl) ester O''-(2-methoxy-1-methoxymethyl-ethyl) ester 
• 28253-68-1 Thiophosphoric acid O-ethyl ester O'-(4-methanesulfinyl-3-methyl-phenyl) ester O''-(2-methoxy-1-methoxymethyl-ethyl) ester 
• 28372-43-2 Thiophosphoric acid O-ethyl ester O'-(2-methoxy-1-methoxymethyl-ethyl) ester O''-(4-nitro-phenyl) ester 
• 28239-91-0 Thiophosphoric acid O-(4-methanesulfonyl-phenyl) ester O'-(2-methoxy-1-methoxymethyl-ethyl) ester O''-methyl ester 
• 28239-90-9 Thiophosphoric acid O-ethyl ester O'-(4-methanesulfonyl-phenyl) ester O''-(2-methoxy-1-methoxymethyl-ethyl) ester 
• 28253-79-4 Thiophosphoric acid O-(2-chloro-4-nitro-phenyl) ester O'-ethyl ester O''-(2-methoxy-1-methoxymethyl-ethyl) ester 

Relevant academic research and scientific papers

Thermodynamic characteristics of the sorption of glycerol ethers on stationary phase OV-101

Retention characteristics, temperature dependences of the retention characteristics, and thermodynamic characteristics of sorption on the nonpolar OV-101 phase are determined for 33 glycerol mono-, di-, and triethers with linear and branched monobasic alc

1,2,3-Trimethoxypropane and glycerol ethers as bio-sourced solvents from glycerol: Synthesis by solvent-free phase-transfer catalysis and utilization as an alternative solvent in chemical transformations

1,2,3-Trimethoxypropane (2), 1-alkoxy-2,3-dimethoxy-propanes, and 1-aryloxy-2,3-dimethoxypropanes were prepared in good yields and selectivity by solid-liquid phase-transfer catalysis in the presence of an inorganic base and an ammonium salt as the phase-transfer catalyst with no additional solvent. No heating was required, and the synthesis was easily performed under atmospheric pressure on a 150g scale. For the preparation of 2, the conversion of glycerol was complete and the selectivity for the expected glycerol trimethylether was above 95%. This product was utilized as a solvent in organic reactions such as transesterifications between glycerol and vegetable oil, organometallic reactions (Grignard- and Barbier-type reactions), carbon-carbon coupling reactions (Suzuki, Sonogashira, Heck), and in etherification reactions by dehydrogenative alkylation. The solvent showed interesting properties for the solubilization of polymers.

Cyclopentadienyl and pentamethylcyclopentadienyl ruthenium complexes as catalysts for the total deoxygenation of 1,2-hexanediol and glycerol

The ruthenium aqua complexes [cp*Ru(OH2)(N-N)](OTf) (cp* = η5-pentamethylcyclopentadienyl, N-N = 2,2′-bipyridine, phen = 1,10-phenanthroline, OTf- = trifluoromethanesulfonate) and the acetonitrile complex [cpRu(CH 3CN)(bipy)](OTf) (cp = η5-cyclopentadienyl) are water-, acid-, and thermally stable (>200°C) catalysts for the hydrogenation of aldehydes and ketones in sulfolane solution. In the presence of HOTf as a co-catalyst, they effect the deoxygenation of 1,2-hexanediol to 1-hexanol and hexane. Glycerol is deoxygenated to 1-propanol in up to 18% yield and under more forcing conditions completely deoxygenated to propene. The structure of the acetonitrile pro-catalyst [cpRu(CH3CN)(bipy)](OTf) has been determined by X-ray crystallography (space group P1 (a = 9.3778(10) A; b = 10.7852(10) A; c = 11.1818(13) A; α = 101.718(5)°; β = 114.717(4)°; γ = 102.712(5)°; R = 3.95%).