1,3-Dimethoxy-2-propanol

Base Information

• Chemical Name: 1,3-Dimethoxy-2-propanol
• CAS No.: 623-69-8
• Molecular Formula: C5H12 O3
• Molecular Weight: 120.148
• Hs Code.: 2909498090
• NSC Number: 263483
• UNII: A0JF0DT9XK
• DSSTox Substance ID: DTXSID30211364
• Nikkaji Number: J6.846B
• Wikidata: Q27273467
• Mol file: 623-69-8.mol

Synonyms:1,3-DIMETHOXY-2-PROPANOL;1,3-dimethoxypropan-2-ol;623-69-8;2-Propanol, 1,3-dimethoxy-;Glycerin 1,3-dimethyl ether;Glycerol 1,3-dimethyl ether;UNII-A0JF0DT9XK;A0JF0DT9XK;AI3-03551;1,3-dimethoxy-2-hydroxypropane;MFCD01076303;NSC-263483;NSC263483;2-Propanol,3-dimethoxy-;C(O)(COC)COC;1,3-dimethoxy-propan-2-ol;glycerol-1,3-dimethyl ether;SCHEMBL55052;DTXSID30211364;AMY25050;BCP31720;AKOS006345951;CS-W018661;NSC 263483;AS-17261;SY021402;LS-122154;A8628;FT-0652031;EN300-97405;2-(1H-Indol-3-yl)-2-oxo-ethylaminehydrochloride;Q27273467

Chemical Property of 1,3-Dimethoxy-2-propanol

Chemical Property:

• Vapor Pressure: 0.415mmHg at 25°C
• Refractive Index: 1.4192
• Boiling Point: 172.6 °C at 760 mmHg
• PKA: 13.68±0.20(Predicted)
• Flash Point: 58.2 °C
• PSA: 38.69000
• Density: 0.987 g/cm³
• LogP: -0.35990
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 120.078644241
• Heavy Atom Count: 8
• Complexity: 40.9

Purity/Quality:

99% ^*data from raw suppliers

1,3-Dimethoxy-2-propanol ^*data from reagent suppliers

Safty Information:

• Statements: 10
• Safety Statements: 16

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC(COC)O
• Uses: 1,3-Dimethoxy-2-propanol is a possbile antiknock additive for gasoline and diesel fuel. It is also used to prepare heteroarylcarbamoylbenzene derivatives as glucokinase activators.

Technology Process of 1,3-Dimethoxy-2-propanol

There total 6 articles about 1,3-Dimethoxy-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → glycerol 1-monomethyl ether (623-39-2,36887-04-4) + 2,3-dimethoxypropan-1-ol (40453-77-8) + 1,3-dimethyl glycerol ether (623-69-8)

Guidance literature:

With trifluorormethanesulfonic acid; (acetonitrile)(2,2'-bipyridine)(η5-cyclopentadienyl)ruthenium(II) triflate; hydrogen; In sulfolane; at 200 ℃; for 3.5h; under 25877.6 Torr; Autoclave;

DOI:10.1039/c0gc00255k

Reference yield:

methanol (67-56-1) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → glycerol 1-monomethyl ether (623-39-2,36887-04-4) + 2,3-dimethoxypropan-1-ol (40453-77-8) + 1,3-dimethyl glycerol ether (623-69-8) + 1,2,3-trimethoxy glycerol ether (20637-49-4)

Guidance literature:

With trifluorormethanesulfonic acid; aqua(2,2'-bipyridine)(η5-pentamethylcyclopentadienyl)ruthenium(II) triflate; hydrogen; In sulfolane; at 200 ℃; for 3.5h; under 25877.6 Torr; Autoclave;

DOI:10.1039/c0gc00255k

Reference yield:

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) + dimethyl sulfate (77-78-1) → glycerol 1-monomethyl ether (623-39-2,36887-04-4) + 2,3-dimethoxypropan-1-ol (40453-77-8) + 1,3-dimethyl glycerol ether (623-69-8) + 1,2,3-trimethoxy glycerol ether (20637-49-4)

Guidance literature:

glycerol; With tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.5h;

dimethyl sulfate; In tetrahydrofuran; at 15 - 20 ℃; for 24h; Solvent;

DOI:10.1002/cctc.201300458

upstream raw materials:

glycerol

dimethyl sulfate

methanol

methyl iodide

Downstream raw materials:

2-Chlor-1,3-dimethoxy-propane

1,3-dimethoxypropan-2-one

1,3-dimethoxypropan-2-yl methanesulfonate

[2-methoxy-1-(methoxymethyl)ethyl]-4-methylbenzenesulfonate