62307-54-4

Upstream product

• 13122-90-2 Boc-Phe-Phe-OH 
• 623-33-6 glycine ethyl ester hydrochloride 
• 30189-51-6 ethyl (N-tert-butoxycarbonyl-L-phenylalanyl)glycinate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 13122-89-9 (S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-3-phenylpropanoate 
• 41041-68-3 L-phenylalanyl-glycine ethyl ester*HCl 

Downstream Products

• 73148-99-9 N-t-Boc-Phe-Phe-Gly-Leu-Met-NH₂ 
• 62307-58-8 H-Phe-Phe-GlyOEt 
• 143674-16-2 pGlu-Phe-Phe-Gly-NHOH 
• 62307-62-4 pGlu-Phe-Phe-Gly-OEt 
• 55572-15-1 L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methionine carboxamide hydrochloride 
• 82816-83-9 HCl*Phe-Phe-Gly-Phe-Met-NH₂ 
• 82816-79-3 Boc-Phe-Phe-Gly-Phe-Met-NH₂ 
• 173174-67-9 [(S)-2-((S)-2-{[(2S,3S,4S)-3-Carbamoylmethyl-4-isopropenyl-1-((S)-5-oxo-1-trityl-pyrrolidine-2-carbonyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-3-phenyl-propionylamino]-acetic acid ethyl ester 
• 143674-15-1 HCl*H-Phe-Phe-Gly-OEt 
• 97207-35-7 Boc-Phe-Phe-Gly-NHOH 
• 82816-76-0 N-tert-butoxycarbonyl-L-phenylalanine-L-phenylalanine-glycine 

Relevant academic research and scientific papers

HMDO-promoted peptide and protein synthesis in ionic liquids

Hexamethyldisiloxane (HMDO) has been developed to efficiently promote the metal-free direct coupling of an amino function of one cysteine-free peptide or protein and a C-terminal thioester of the second peptide in ionic liquids. The amide-coupling reaction proceeds smoothly under mild conditions to afford the corresponding products in good to excellent yields (63-94%). Peptide couplings were also achieved using in-situ-generated thioesters by the thioesterification of oxo esters.

Synthesis and biological activity of peptide hydroxamate inhibitors of degradation of substance P analogues

A series of hydroxamic acid derivatives of peptides related to fragments of substance P (SP) were synthesized.Methyl, ethyl or N-hydroxy-succinimide ester precursors of the desired peptides were prepared by using classical peptide synthesis methodology an

SYNTHESIS OF PENTAPEPTIDES RELATED BOTH TO SUBSTANCE P C-TERMINAL FRAGMENT AND MET-ENKEPHALIN

Six pentapeptide amides related both to Substance P C-terminal fragment and to Met-enkephalin have been synthesized.Syntheses were effected by coupling fragments 3 + 2 in solution.The DCC + HOBt method was used for synthesis of peptide fragments and final