62311-85-7Relevant academic research and scientific papers
Intramolecular Free Radical Functionalisation of the Methyl Group of 5'-Deoxyadenosine
Gani, David,Johnson, Alan W.,Lappert, Michael F.
, p. 3065 - 3069 (1981)
Formation (2 methods) of a free radical at the 8-position of 5'-deoxy-2',3'-O-isopropylideneadenosine causes cyclisation with the 5'-methyl group to give, in yields of up 80percent, 5'-deoxy-2',3'-O-isopropylidene-5',8-cycloadenosine, identical with the p
Intramolecular Free-radical Functionalisation of the Methyl Group of 5'-Deoxyadenosine
Gani, David,Johnson, Alan W.,Lappert, Michael F.
, p. 1244 - 1245 (2007/10/02)
Anaerobic irradiation of 2',3'-O-isopropylidene-8-phenylthio-5'-deoxyadenosine in the presence of t-butyl hydroperoxide causes rapid conversion into the 5',8-cycloadenosine, formed by reaction of the C(8)-radical with the neighbouring 5'-methyl group; this provides an in vitro analogy for the functionalisation of this methyl group involved in many of the coenzyme B12-controlled rearrangement reactions.
