76994-99-5

Upstream product

• 67-56-1 methanol 
• 76995-01-2 8-bromo-5’-deoxy-2’,3’-O-isopropylideneadenosine 
• 930-69-8 sodium thiophenolate 
• 108-98-5 thiophenol 
• 57731-91-6 O^2'_,O3'-isopropylidene-5'-deoxy-adenosine 
• 362-75-4 2',3'-isopropylidene adenosine 
• 892-48-8 5'-deoxy-5'-chloroadenosine 
• 24514-56-5 9-((3aR,4R,6S,6aS)-6-(chloromethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine 
• 62311-85-7 5'-deoxy-5'-phenylthio-2',3'-O-isopropylideneadenosine 

Relevant academic research and scientific papers

Intramolecular Free-radical Functionalisation of the Methyl Group of 5'-Deoxyadenosine

Anaerobic irradiation of 2',3'-O-isopropylidene-8-phenylthio-5'-deoxyadenosine in the presence of t-butyl hydroperoxide causes rapid conversion into the 5',8-cycloadenosine, formed by reaction of the C(8)-radical with the neighbouring 5'-methyl group; this provides an in vitro analogy for the functionalisation of this methyl group involved in many of the coenzyme B12-controlled rearrangement reactions.

Intramolecular Free Radical Functionalisation of the Methyl Group of 5'-Deoxyadenosine

Formation (2 methods) of a free radical at the 8-position of 5'-deoxy-2',3'-O-isopropylideneadenosine causes cyclisation with the 5'-methyl group to give, in yields of up 80percent, 5'-deoxy-2',3'-O-isopropylidene-5',8-cycloadenosine, identical with the p