62317-42-4Relevant academic research and scientific papers
Addition of halide to π-bond directly from aqueous NaX solution: A general strategy for installation of two different functional groups
Pandit, Palash,Gayen, Krishnanka S.,Khamarui, Saikat,Chatterjee, Nirbhik,Maiti, Dilip K.
supporting information; experimental part, p. 6933 - 6935 (2011/08/06)
Activation of π-bond with organic Lewis acid and cationic surfactant mediated direct transfer of halides to alkyne and alkene are demonstrated to afford α,α-dihaloketones and other valuable synthons with outstanding selectivities.
Chemoenzymatic approach to optically active phenylglycidates: Resolution of bromo- and iodohydrins
Anand, Naveen,Kapoor, Munish,Koul, Surrinder,Taneja, Subhash C.,Sharma, Rattan L.,Qazi, Ghulam N.
, p. 3131 - 3138 (2007/10/03)
Enantiomerically enriched phenylglycidates, precursors of the taxol C-13 phenylisoserine side chain and diltiazem, were prepared by kinetic resolution of anti-2-bromo-3-hydroxy- and anti-3-hydroxy-2-iodophenylpropanoates to provide enantioriched (2R,3R)- and (2S,3S)-halohydrins. The bulkiness and inflexibility of bromo and iodo groups in halohydrins have made them inaccessible to the active site of most of the lipases utilized for the hydrolysis of their acyloxy derivatives. In a set of 22 hydrolases screened herein, including native as well as commercial enzymes, only Aspergillus niger (Lipase AS, AMANO) could catalyze the hydrolysis with high enantioselectivity (E = 176). The resolved halohydrins easily underwent transformation to the corresponding (2S,3R)- and (2R,3S)-phenylglycidates.
Stereoselective chemoenzymatic process for the preparation of optically enriched phenylglycidates as precursors of taxol side chain
-
Page 4, (2008/06/13)
The present invention relates to a novel and efficient chemoenzymatic process of preparation of optically active trans alkyl phenylglycidates. The invention particularly discloses a novel process for the chemoenzymatic synthesis of two enantiomers of tran
