20485-39-6

Basic information

• Product Name: Ethyl 4-methyl-1,3-oxazole-5-carboxylate
• Synonyms: 4-METHYL-OXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;ETHYL 4-METHYL-1,3-OXAZOLE-5-CARBOXYLATE;ethyl 4-methyloxazole-5-carboxylate;EINECS 243-848-9;Ethyl 4-Methyloxazole-5-carboxylate, 97+%;5-(Ethoxycarbonyl)-4-methyl-1,3-oxazole;4-methyl-1,3-oxazole-5-carboxylate
• CAS NO: 20485-39-6
• Molecular Formula: C₇H₉NO₃
• Molecular Weight: 155.15
• EINECS: 243-848-9
• Product Categories: Esters;Oxazoles, Isoxazoles & Benzoxazoles;Oxazoles, Isoxazoles & Benzoxazoles
• Mol File: 20485-39-6.mol
• Article Data: 14

Chemical Properties

• Melting Point: 38 °C
• Boiling Point: 62°C/1.5mmHg(lit.)
• Flash Point: 96.1 °C
• Appearance: /
• Density: 1.139 g/cm³
• Vapor Pressure: 0.268mmHg at 25°C
• Refractive Index: 1.4680 to 1.4720
• Storage Temp.: 2-8°C
• PKA: -0.80±0.14(Predicted)
• CAS DataBase Reference: Ethyl 4-methyl-1,3-oxazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-methyl-1,3-oxazole-5-carboxylate(20485-39-6)
• EPA Substance Registry System: Ethyl 4-methyl-1,3-oxazole-5-carboxylate(20485-39-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 20485-39-6(Hazardous Substances Data)

Usage

General Description

Ethyl 4-methyl-1,3-oxazole-5-carboxylate is a chemical compound that can be classified as a member of the oxazole family. It is typically characterized by the presence of a five-membered aromatic ring that comprises of three carbon atoms, one oxygen atom and one nitrogen atom. The specific structure of this chemical entails the carboxylate functional group at one end and the ethyl group at the other end. This structure points to the existence of both polar and nonpolar regions within the molecule, meaning it might have diverse chemical reactivity. Its exact behaviour, uses, or hazards in the chemical and industrial settings are not widely known, thus caution should be exercised while handling this compound.

InChI:InChI=1/C7H9NO3/c1-3-10-7(9)6-5(2)8-4-11-6/h4H,3H2,1-2H3

Upstream product

• 141-97-9 ethyl acetoacetate 
• 77287-34-4 formamide 
• 584-08-7 potassium carbonate 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 16712-16-6 ammonium formate 
• 64-18-6 formic acid 
• 638-07-3 ethyl (2-chloroaceto)acetate 

Downstream Products

• 2510-32-9 4-methyl-1,3-oxazole-5-carboxylic acid 
• 933782-12-8 2-cyclohexyl-4-ethoxycarbonyl-4-methyl-1,3-oxazole 
• 1387556-68-4 ethyl 2-(5-(ethoxycarbonyl)-4-methylthiazol-2-yl)-4-methyloxazole-5-carboxylate 
• 3944-31-8 diethyl 4,4?-dimethyl-2,2?-bithiazole-5,5?-dicarboxylate 
• 1403502-53-3 ethyl 4-methyl-2-p-tolyloxazole-5-carboxylate 
• 45515-23-9 5-hydroxymethyl-4-methyloxazole 
• 863679-31-6 3-[(3-chloropropyl)sulfanyl]-4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazole 
• 1003-52-7 5-cyano-4-methyl-oxazole 
• 106166-54-5 4-methyl-5-(4-phenyl-thiazol-2-yl)-oxazole 
• 45515-22-8 4-methyl-5-oxazolylmethyl chloride 
• 62348-24-7 4-Methyl-5-oxazolecarbonyl chloride 
• 911297-49-9 6-[2-(4-methyl-oxazole-5-carbonyl)-phenyl]-hept-2-en-4-ynoic acid ethyl ester 
• 911297-36-4 (4-methyl-oxazol-5-yl)-[2-(1-methyl-3-trimethylsilanyl-prop-2-ynyl)-phenyl]methanone 

Relevant articles and documents

Synthesis of oxazolyl- and furanyl-substituted imidazole hydrochlorides and methiodides

Oxazolyl-5- and furanyl-2-substituted imidazoles have been synthesized by coupling the two ring systems via the dipolar cycloadditon of tosyl methyl isocyanide to the corresponding oxazolyl and furanyl aldimines in basic media. These substitute oxazolyl and furanylimidazole bases obtained in this manner were then subjected to hydrogen chloride gas and to methyl iodide to form the corresponding hydrochlorides and methyliodides, respectively. All compounds were purified, characterized and then tested for muscarinic binding affinity. Biological test results revealed low muscarinic receptor affinity and selectivity.

Synthesis of oxazolyl-substituted morpholinium salts

Morpholinium salts coupled to oxazolyl moieties have been synthesized via nucleophilic substitution of a series of oxazolyl chlorides with morpholine. The oxazole moieties were first synthesized and then coupled with morpholine. The corresponding hydrochloride and methyl iodide salts were obtained, purified, characterized and then tested for muscarinic receptor binding affinity. Biological test results from MDS Pharma Services revealed no significant muscarinic receptor affinity.

3-(AZOLYLMETHOXY)BIPHENYL DERIVATIVES AS INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION

The present invention provides novel compounds of formula (I) that are useful as inhibitors of the PD-1/PD-L1 protein/protein interaction. The compounds may be used in the treatment of cancer, infectious diseases and neurodegenerative diseases such as schizophrenia, Alzheimer, multiple sclerosis or Parkinson.

NEW INTERMEDIATE COMPOUND FOR PREPARING VITAMIN B6

Provided is a new intermediate compound for preparing vitamin B6, which can be used to synthesize the known intermediate compound for preparing vitamin B6, 4-methyloxazole-5-carboxyLate. Further provided is a process for preparing the new intermediate compound and a process for preparing the known intermediate compound 4-methyloxazole-5-carboxylate from the new intermediate compound.