623573-77-3

Upstream product

• 106511-80-2 methyl N-(2-methoxycarbonylphenyl)dithiocarbamate 
• 16024-82-1 methyl 2-isothiocyanatobenzoate 
• 100-46-9 benzylamine 
• 261509-54-0 3-amino-2-methylsulfanyl-3H-quinazolin-4-one 
• 16951-33-0 3-amino-2-mercapto-3H-quinazolin-4-one 
• 134-20-3 2-carbomethoxyaniline 

Downstream Products

• 936501-61-0 C₆H₅CH₂C₉H₄N₄OCH₂Cl 

Relevant academic research and scientific papers

Synthesis and antihypertensive activity of novel 3-benzyl-2-substituted-3H-[1,2,4]triazolo[5,1-b]quinazolin-9-ones

A series of 3-benzyl-2-substituted-3H-[1,2,4]triazolo[5,1-b]quinazolin-9-ones have been synthesized by the cyclocondensation of 3-amino-2-benzylamino-3H-quinazolin-4-one with a variety of one-carbon donors. The starting material 3-amino-2-benzylamino-3H-quinazolin-4-one was synthesized from methyl anthranilate by a novel innovative route. The title compounds were evaluated for their in vivo antihypertensive activity using spontaneously hypertensive rats (SHR). While all the test compounds exhibited significant antihypertensive activity, 3-benzyl-2-methyl-3H-[1,2,4]triazolo[5,1-b] quinazolin-9-one exhibited antihypertensive activity more than the reference standard prazocin.

Synthesis, analgesic and anti-inflammatory activities of some novel 2,3-disubstituted quinazolin-4(3H)-ones.

A series of novel 2-benzylamino-3-substituted quinazolin-4(3H)-ones have been synthesized by treating 3-amino-2-benzylamino quinazolin-4(3H)-one, with different aldehydes and ketones. The starting material 3-amino-2-benzylamino quinazolin-4(3H)-one was sy