623583-12-0Relevant academic research and scientific papers
The synthesis and biological activity of C2-fluorinated pyrrolo[2,1-c][1,4]benzodiazepines
O'Neil, Ian A.,Thompson, Stephen,Kalindjian, S. Barret,Jenkins, Terence C.
, p. 7809 - 7812 (2003)
The novel C2-fluorinated pyrrolobenzodiazepines (1, 2 and 3) have been prepared from commercially available trans-hydroxyproline in good overall yield and were screened for in vitro cytotoxicity against a number of cancer cell lines. The 2R-fluoro isomer 2 exhibits an activity of 76 nM against the CH1 cell line.
