623583-15-3

Upstream product

• 1138324-48-7 (2S,4R)-tert-butyl 4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 51-35-4 4R-4-hydroxyproline 
• 203866-18-6 methyl (2S,4R)-N-(tert-butyloxy)carbonyl-4-fluoropyrrolidine-2-carboxylate 
• 74844-91-0 (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 
• 31162-13-7 2-azidobenzoic acid 
• 623583-12-0 (2-Azido-phenyl)-((2S,4R)-4-fluoro-2-hydroxymethyl-pyrrolidin-1-yl)-methanone 

Relevant academic research and scientific papers

The synthesis and biological activity of C2-fluorinated pyrrolo[2,1-c][1,4]benzodiazepines

The novel C2-fluorinated pyrrolobenzodiazepines (1, 2 and 3) have been prepared from commercially available trans-hydroxyproline in good overall yield and were screened for in vitro cytotoxicity against a number of cancer cell lines. The 2R-fluoro isomer 2 exhibits an activity of 76 nM against the CH1 cell line.