62367-59-3

Basic information

• Product Name: (S)-3-Hydroxy-1-methyl-piperidine
• Synonyms: (S)-3-Hydroxy-1-methyl-piperidine;(S)-3-Hydroxy-1-Methyl-pi...;(3S)-1-methylpiperidin-3-ol
• CAS NO: 62367-59-3
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.17352
• Mol File: 62367-59-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 177.6±0.0 °C(Predicted)
• Appearance: /
• Density: 1.005±0.06 g/cm3(Predicted)
• PKA: 14.95±0.20(Predicted)
• CAS DataBase Reference: (S)-3-Hydroxy-1-methyl-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-Hydroxy-1-methyl-piperidine(62367-59-3)
• EPA Substance Registry System: (S)-3-Hydroxy-1-methyl-piperidine(62367-59-3)

Safety Data

• Hazardous Substances Data: 62367-59-3(Hazardous Substances Data)

Usage

General Description

(S)-3-Hydroxy-1-methyl-piperidine is a chemical compound with the molecular formula C6H13NO. It is a piperidine derivative, which is a type of organic compound that contains a six-membered ring structure with five carbon atoms and one nitrogen atom. This specific compound has a hydroxy group (-OH) and a methyl group (-CH3) attached to the piperidine ring. It is commonly used as a pharmaceutical intermediate in the synthesis of various drugs and biologically active compounds. The compound may have potential pharmacological applications due to its structural features and reactivity in chemical reactions. However, further research and testing are needed to fully understand its potential uses and effects.

Upstream product

• 475058-41-4 (S)-3-hydroxypiperidine hydrochloride 
• 50-00-0 formaldehyd 
• 99176-14-4 1-methyl-3-piperidinyl butyrate 
• 3554-74-3 3-Hydroxy-1-methylpiperidine 
• 108-05-4 vinyl acetate 
• 6659-33-2 (±)-3-acetoxy-N-methylpiperidine 
• 5519-50-6 1-methyl-3-piperidone 

Downstream Products

• 1428555-21-8 C₁₃H₁₅F₃N₂O₃ 
• 1428555-13-8 C₂₁H₂₄BrF₃N₂O₅S 
• 1613045-94-5 (S)-1-methylpiperidin-3-yl 2-hydroxy-2,2-diphenylacetate 

Relevant articles and documents

Implementation of biocatalysis in continuous flow for the synthesis of small cyclic amines

Significant progress has been made in establishing transaminases as robust biocatalysts for the green and scalable synthesis of a diverse range of chiral amines.[1] However, very few examples on the amination of small cyclic ketones have been reported.[2] Cyclic ketones are particularly challenging for transaminase enzymes because they do not display the well-defined small and large substituent areas that are characteristic for the biocatalytic mechanism. In this work, we exploited the broad substrate scope of the (S)-selective transaminase from Halomonas elongata (HeWT) to develop an efficient biocatalytic system in continuous flow to generate a range of small cyclic amines which feature very often in pharmaceuticals and agrochemicals.[3] Tetrahydrofuran-3-one and other challenging prochiral ketones were rapidly (5-45 min) transformed to their corresponding amines with excellent molar conversion (94-99%) and moderate to excellent ee.

Preparation of (R)-3-hydroxy-n-methylpiperidine, a synthetic key intermediate of (R)-mepenzolate, based on the lipase-catalyzed resolution of the racemic form

In this study, a two-step method for the gram-scale synthesis of (R)-3-hydroxy-N-methylpiperidine in 97.8% enantiomeric excess (ee) is reported. The key chiral synthetic intermediate of (R)-mepenzolate was formed in 22% yield over two steps using a commer

Simple one-pot process for the bioresolution of tertiary amino ester protic ionic liquids using subtilisin

An efficient hydrolase-catalyzed bioresolution of tertiary amino ester protic ionic liquids has been demonstrated. Protic ionic liquids have been prepared in one step from the corresponding tertiary amino alcohols by treatment with butyric anhydride. Afte