62373-64-2Relevant academic research and scientific papers
Size of gold nanoparticles driving selective amide synthesis through aerobic condensation of aldehydes and amines
Miyamura, Hiroyuki,Min, Hyemin,Soulé, Jean-Fran?ois,Kobayashi, Shu
supporting information, p. 7564 - 7567 (2015/06/25)
Metal nanoparticles (NPs) have attracted much attention in many fields due to their intrinsic characteristics. It is generally accepted that smaller NPs (1.5-3 nm) are more active than larger NPs, and reverse cases are very rare. We report here the direct aerobic oxidative amide synthesis from aldehydes and amines catalyzed by polymer-incarcerated gold (Au) NPs. A unique correlation between imine/amide selectivity and size of NPs was discovered; Au-NPs of medium size (4.5-11 nm) were found to be optimal. High yields were obtained with a broad range of substrates, including primary amines. Au-NPs of medium size could be recovered and reused several times without loss of activity, and they showed good activity and selectivity in amide formation from alcohols and amines. Superior activity and selectivity of gold nanoparticles (Au-NPs) of medium size (4.5-11 nm) were found for the direct and selective aerobic oxidative amide synthesis from various combinations of aldehydes and amines. This is an example of an unusual correlation between the size of NPs and their activity/selectivity. These catalysts could be recovered and reused several times without loss of activity.
Novel syntheses of alpha-morpholinoamides from alpha,alpha-dichloroacetamides.
Katritzky, Alan R,Zhang, Yuming,Singh, Sandeep K
, p. 8239 - 8242 (2007/10/03)
Dichloroacetamides, on heating with benzotriazole, morpholine, and triethylamine, produce, in a one-pot reaction, alpha-benzotriazolyl-alpha-morpholinoacetamides 4a,b. Intermediates 4a and 4b react with nucleophiles such as allylsilanes, silyl ethers, and organozinc reagents to afford diverse alpha-morpholinoamides.
N-benzyl-2,2-dimethoxy-acetamides
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, (2008/06/13)
N-benzyl-2,2-dimethoxy-acetamides having the formula STR1 and processes for preparing the same. These acetamides are useful for the production of 2H-3-isoquinolones by acid cyclization and said 2H-3-isoquinolones are in turn useful as starting materials inter alia in the synthesis of 1,4-dihydro-1,4-etheno-isoquinolin-3(2H)ones, which are valuable chemotherapeutic agents as disclosed in U.S. Pat. No. 3,781,436.
