624-08-8Relevant academic research and scientific papers
Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteria
Davis, Chris B.,Hartnell, Regan D.,Madge, Paul D.,Owen, David J.,Thomson, Robin J.,Chong, Andrew K.J.,Coppel, Ross L.,Von Itzstein, Mark
, p. 1773 - 1780 (2007)
As part of our research interest directed toward the development of antimycobacterial agents, we have investigated compounds based on galactofuranose (Galf), an essential cell wall component of mycobacteria. The objective of this study was to explore stru
Long-chain alkyl ester amine compound or fluorine-containing long-chain alkyl ester amine compound and kilogram-level preparation method thereof
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Paragraph 0131-0132; 0153; 0190-0191; 0193, (2021/09/15)
The invention discloses a long-chain alkyl ester amine compound or a fluorine-containing long-chain alkyl ester amine compound and a kilogram-level preparation method thereof. According to the method, a product is obtained at a high yield in synthesis of a first part of halogenated long-chain alkyl ester and halogenated polyfluoroalkyl long-chain ester, and the product is obtained at a yield of 90% in the kilogram-level preparation process. In the process, column chromatography is not needed, the product can be obtained directly through distillation or reduced pressure distillation, and the method has obvious advantages in the aspects of production route and synthesis cost. In the step-by-step amination of the second part, by-products are prevented from being generated by controlling reaction conditions, and the final target product is obtained in the two steps at the yield of 90% or above.
IONIZABLE AMINE LIPIDS AND LIPID NANOPARTICLES
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Page/Page column 157; 158; 161; 162, (2020/11/04)
The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions.
Bridging Small Molecules to Conjugated Polymers: Efficient Thermally Activated Delayed Fluorescence with a Methyl-Substituted Phenylene Linker
Rao, Jiancheng,Liu, Xinrui,Li, Xuefei,Yang, Liuqing,Zhao, Lei,Wang, Shumeng,Ding, Junqiao,Wang, Lixiang
supporting information, p. 1320 - 1326 (2019/12/24)
Based on a “TADF + Linker” strategy (TADF=thermally activated delayed fluorescence), demonstrated here is the successful construction of conjugated polymers that allow highly efficient delayed fluorescence. Small molecular TADF blocks are linked together
Long-Range Self-Assembly of an Electron-Deficient Hexaazatrinaphthylene with Out-of-Plane Substituents
Chen, Yi-Ru,Zhang, Yong-Yun,Yeh, Ming-Che,Luo, Ying-Ting,Ong, Chi Wi
, p. 613 - 618 (2019/12/24)
The unprecedented time-dependent long-range supramol-ecular assembly of electron-deficient hexaazatrinaphthylene (HATN) core based on peripheral crowding with three out-of-plane cyclic ketals is reported. The single-crystal X-ray structure of the diethyl derivative provided detailed information as to how four molecules in a repeating unit were packed in order to avoid steric crowding of the out-of-plane cyclic ketal side chain, providing locking and fastening for stabilizing the self-assembled structure. The polarizing optical microscopy (POM) and differential scanning calorimetry (DSC) did not instantaneously show any phase transition upon the cooling process. To our surprise, POM images showed a nucleation of spherulite up to 100 μm after 24 hour later. X-ray diffraction data further confirmed that these soft crystal formed a hexagonal-like crystal. The long-range self-assembly of the new material showed a slight red shift in the UV-vis absorption spectra and further substantiated by computational method.
A General and Air-tolerant Strategy to Conjugated Polymers within Seconds under Palladium(I) Dimer Catalysis
Magnin, Guillaume,Clifton, Jamie,Schoenebeck, Franziska
supporting information, p. 10179 - 10183 (2019/06/25)
While current M0/MII based polymerization strategies largely focus on fine-tuning the catalyst, reagents and conditions for each and every monomer, this report discloses a single method that allows access to a variety of different conjugated polymers within seconds at room temperature. Key to this privileged reactivity is an air- and moisture stable dinuclear PdI catalyst. The method is operationally simple, robust and tolerant to air.
IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
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, (2018/07/04)
What is described is a compound of formula I consisting of a compound in which R1 is a branched chain alkyl consisting of 10 to 31 carbons; R2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons; L1 and L2 are the same or different, each a linear alkylene of 1 to 20 carbons or a linear alkenylene of 2 to 20 carbons; X1 is S or O; R3 is a linear or branched alkylene consisting of 1 to 6 carbons; and R4 and R5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.
IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
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, (2018/07/05)
What is described is a compound of formula I consisting of a compound in which R1 is a branched chain alkyl consisting of 10 to 31 carbons;R2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons, or a branched chain alkyl consisting of 10 to 31 carbons;L1 and L2 are the same or different, each a linear alkane of 1 to 20 carbons or a linear alkene of 2 to 20 carbons;X1 is S or O;R3 is a linear or branched alkylene consisting of 1 to 6 carbons; andR4 and R5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.
Carbazole-based π-conjugated polyazomethines: Effects of catenation and comonomer insertion on optoelectronic features
Garbay,Muccioli,Pavlopoulou,Hanifa,Hadziioannou,Brochon,Cloutet
, p. 274 - 284 (2017/05/31)
A series of carbazole-based polyazomethines have been synthesized under micro-wave irradiation and without transition-metal based catalyst. The impact of both the catenation brought by the carbazole subunits and the insertion of a co-monomer, i.e. 3,4 ethylene dioxythiophene (EDOT), on the optical and electrochemical properties have been studied. Among the different polyazomethines synthesized, the best in terms of optical and electrochemical properties has been found to be the one with the azomethine function linked in positions 2,7 of carbazole subunits. Upon the insertion of the EDOT comonomer, an increase of the molecular weight and a red-shift in the absorption spectra has been observed, corresponding to a diminution of the electronic gap.
COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
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Paragraph 00427, (2017/04/11)
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
