62427-27-4

Upstream product

• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 106-48-9 4-chloro-phenol 
• 698-63-5 5-nitrofurane-2-carboxaldehyde 
• 21508-19-0 5-chloro-2-furaldehyde 
• 82386-82-1 2-Fural-5-trimethylammonium chloride 

Downstream Products

• 73420-67-4 5-(4-chlorophenoxy)-2-furanoic acid 
• 93104-93-9 5-(4-chlorophenoxy)-2-furancarbonitrile 
• 78427-16-4 2-[5-(4-Chloro-phenoxy)-furan-2-ylmethylene]-malononitrile 

Relevant academic research and scientific papers

NOVEL ANTIMALARIA AGENT CONTAINING HETEROCYCLIC COMPOUND

Disclosed is an antimalarial agent containing a compound represented by the formula: [wherein A1 represents a 3-pyridyl group that may have a substituent, a 6-quinolyl group that may have a substituent, or the like; X1 represents a group represented by the formula -C(=O)-NH- or the like; E represents a furyl group, a thienyl group or a phenyl group; with the proviso that A1 may have one to three substituents, and E has one of two substituents] or a salt thereof or hydrates thereof.

NOVEL ANTIFUNGAL AGENT COMPRISING HETEROCYCLIC COMPOUND

The present invention provides an antifungal agent represented by the formula: [wherein A1 represents a 3-pyridyl group which may have a substituent, a quinolyl group which may have a substituent, or the like; X1 represents a group represented by the formula -NH-C(=O)-, a group represented by the formula -C(=O)-NH-, or the like; E represents a furyl group, a thienyl group, a pyrrolyl group, a phenyl group, a pyridyl group, a tetrazolyl group, a thiazolyl group or a pyrazolyl group; with the proviso that A1 may have 1 to 3 substituents, and E has one or two substituents].

5-SUBSTITUTED 2-FURANCARBALDEHYDES AND WATER-SOLUBLE FURAN DERIVATIVES

5-Halo-2-furaldehydes Ia, Ib react with trimethylamine in aprotic solvents to furnish 5-trimethylamonium salts of 2-furaldehyde IIa, IIb.The reactivity of this salt was utilized for a simple preparation of 5-substituted 2-furaldehydes IV in water at room temperature.The possibility to synthesize azomethines V and ethylenes VI, having the trimethylammonium group in position 5 of the furan ring maintained, is discussed.

Studies on Furan Derivatives. IX. Nucleophilic Substitution of 5-Nitro-2-furancarbaldehyde: Preparation of 5-Phenoxy-2-furancarbaldehydes

5-(2-, 3-, 4-Substituted phenoxy)-2-furancarbaldehydes were prepared by the reaction of various phenoxides with 5-nitro-2-furancarbaldehyde via replacement of the nitro group.

SYNTHESIS AND POLAROGRAPHIC INVESTIGATION OF 5-PHENOXY-2-FURALDEHYDES

5-(4- Or 3-X-phenoxy)-2-furaldehydes were prepared from 5-bromo-2-furaldehyde and the respective sodium 4- or 3-X-phenolates (X= 4-Cl, 4-Br, 4-NO2, 4-CH3, 3-NO2, 4-CH3O, 4-COOC2H5, 4-SCH3, 3-NHCOCH3 ) in dimethyl sulfoxide.The transmission effect of a sub