6243-71-6

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InChI:InChI=1/C11H16N2/c1-9(2)10(3)12-13-11-7-5-4-6-8-11/h4-9,13H,1-3H3

Upstream product

• 563-80-4 3-methyl-butan-2-one 
• 100-63-0 phenylhydrazine 
• 59-88-1 phenylhydrazine hydrochloride 
• 62-53-3 aniline 

Downstream Products

• 91-55-4 2,3-dimethylindole 
• 1640-39-7 2,3,3-trimethylindoleniune 
• 80278-89-3 5-Isopropyl-3-(4-methoxy-phenyl)-2-phenyl-2,4-dihydro-[1,2,3]diazaphosphole 3-sulfide 
• 73150-74-0 5-isopropyl-5-methyl-2-phenyl-[1,2,4]triazolidin-3-one 
• 148335-26-6 2-(2-anilinovinyl)-1-ethyl-3,3-dimethyl-3H-indolium iodide 
• 14134-81-7 1-ethyl-2,3,3-trimethylindolium iodide 
• 615-15-6 2-Methyl-1H-benzimidazole 
• 17790-93-1 2-isopropyl-1H-indole 
• 64290-01-3 3-(p-Aminophenyl)-3-methyl-2-butanon 
• 131366-39-7 (1-Isocyanato-1,2-dimethyl-propyl)-phenyl-diazene 

Relevant academic research and scientific papers

A carbazole-hemicyanine dye based ratiometric fluorescent probe for selective detection of bisulfite (HSO3 ?) in cells and C. elegans

Bisulfite (HSO3 ?) is an important sulfur dioxide (SO2) derivative, which plays a major role in many physiological processes and is also closely associated with a variety of diseases. Thus the development of highly selective and sensitive fluorescent probes is essential to detect HSO3ˉ in living cells. In this work, we report the synthesis and analysis of a ratiometric fluorescent probe for selective detection of HSO3ˉ based on the 1,4-nucleophilic addition reaction with the carbazole as an electron donor (D) and aldehyde group as an electron acceptor (A). The addition of HSO3ˉ and other ions to our probe can be observed by UV - vis and fluorescence spectrometry. Our investigation proved that the probe is highly selective and sensitive for HSO3ˉ and ratiometric changes. Moreover, the probe has good cell permeability and was successfully applied to the detection of exogenous HSO3ˉ in Hela cells and C. elegans.

Compound with fluorescence resonance energy transfer performance and its application

The invention relates to a compound with fluorescence resonance energy transfer performance and its application. The compound is prepared by trimethine cyanine dye and pentamethine cyanine dye througha proper connecting arm. The compound provided by the invention can be applied to detect active oxygen and active nitrogen, and is not influenced by probe concentration, background fluorescence, instrumental error and other factors; moreover, the compound has relatively high FRET efficiency.

FRET-Based Mito-Specific Fluorescent Probe for Ratiometric Detection and Imaging of Endogenous Peroxynitrite: Dyad of Cy3 and Cy5

Peroxynitrite (OONO-) is profoundly implicated in health and disease. The physiological and pathological outcome of OONO- is related to its local concentration, and hence, a reliable OONO- assay is highly desired. We have developed a FRET-based small-molecule fluorescent probe (PNCy3Cy5), harnessing the differential reactivity of Cy3 and Cy5 toward OONO- by fine-tuning. It exhibits high detection sensitivity and yields a ratiometric fluorescent signal. We have exemplified that it can be applied in semiquantitative determination of OONO- in living cells. Notably, it specifically localizes in mitochondria, where endogenous OONO- is predominantly generated. Thus, PNCy3Cy5 is a promising molecular tool for peroxynitrite biology.

Ratiometric pH fluorescent probe as well as preparation method and application thereof

The invention relates to a ratiometric pH fluorescent probe as well as a preparation method and an application thereof. The chemical structural formula of the fluorescent probe is shown as formula I in the specification, wherein R is -OH or a subcellular organelle positioning receptor, and the subcellular organelle positioning receptor comprises either of two components shown in the specification. Compared with the prior art, the ratiometric pH fluorescent probe has good light stability, high selectivity, wide pH value detection range and high sensitivity, the preparation method is simple, and the ratiometric pH fluorescent probe can be used for detecting the pH value of a chemical system or the pH value in living cells of creatures.

Highly selective visual detection of Cu(II) utilizing intramolecular hydrogen bond-stabilized merocyanine in aqueous buffer solution

A Cu2+-specific colorimetric sensor 1, which is stabilized by an intramolecular hydrogen bonding, was designed and developed. The color of 1 changes from purple to blue on addition of 1.0 μM Cu2+ in aqueous buffer solution, which can be detected by the naked eye. The analytical detection limit for Cu2+ by the naked eye is as low as 1.0 μM. The stoichiometry for 1 and Cu2+ in complex is 2:1 in aqueous solution.

Vilsmeier formylation of hydrazones and semicarbazones derived from alkyl, benzyl, and cycloalkyl methyl ketones

Formylation of ten accessible phenylhydrazones and semicarbazones derived from alkyl, benzyl, and cycloalkyl methyl ketones with the complex of POCl 3 with dimethylformamide was studied. Depending on the electronic and steric structure of the substrates, the reaction yields 1-phenyl- or 1-unsubstituted 3,4-dialkyl-, 3-alkyl-4-aryl-, or 3-alkyl-4-formylpyrazoles. These compounds can be readily oxidized into the corresponding carboxylic acids. 2005 Pleiades Publishing, Inc.

Synthesis and structure of indoline spiropyrans of the coumarin series

New indoline spiropyrans of the coumarin series were synthesized by the condensation of indoline and hydroxyformylcoumarin derivatives. Spiropyrans, viz., derivatives of 8-formyl-7-hydroxy-4-methylcoumarin and 5-formyl-6-hydroxy-4-methylcoumarin, under irradiation are transformed into open forms, which are recyclized in the dark. The compounds formed by the condensation of the indoline derivatives with 3-formyl-4-hydroxycoumarin have an open structure of the merocyanine dyes and are transformed into spiro forms neither in the dark nor under irradiation with the visible light.

Ionic Liquid Promoted Rapid Synthesis of Aryl Hydrazones under Ambient Conditions

Aryl hydrazones have been synthesized in excellent isolated yields (90-96%) in short reaction time (4 min) under ambient conditions in the absence of any added catalyst by the reaction of aryl hydrazines with carbonyl compounds in the ionic liquid 1,3-di-

VISIBLE LIGTH-HARVESTING IN COVALENTLY-LINKED PORPHYRIN-CYANINE DYES

We report the synthesis and properties if three members of a new class of photochemical model compounds containing a covalently-linked porphyrin and a cyanide dye.In compounds 1 and 2 the dye absorbs in the 450-570 nm region and energy transfer occurs with 80percent efficiency from the dye to the free base porphyrin.In compound 3 the dye absorbs in the 650-780 nm region and energy transfer occurs with 80percent efficiency from the free base porphyrin to the dye.The zinc-porphyrin-dyes exhibit both donor and acceptor quenching with only moderate yields of energy transfer.This work is a first step toward the development of an artificial phycobilisome.