6244-54-8Relevant academic research and scientific papers
Facile synthesis of α-hydroxy-α-methyl carboxylic acids by electrochemical carboxylation of methyl aryl ketones
Damodar, Janmanchi,Krishna Mohan, Srinivasulu Reddy,Jayarama Reddy, Srinivasulu Reddy
, p. 399 - 402 (2002)
Electrochemical carboxylation of methyl aryl ketones in the presence of atmospheric pressure of carbon dioxide using platinum cathode and dissolved magnesium anode at constant current density of 10 mA/cm2 gave the corresponding α-hydroxy-α-meth
5,5-Disubstituted-3, 4-dihydroxy-2(5H)-furanones and methods of use therefor
-
, (2008/06/13)
The present invention relates to synthetic methods for the production of both optically active and racemic 5,5-disubstituted-3,4-dihydroxy-2(5H)-furanones; 5-[(4-aryl)-3-butynyl]-3,4-dihydroxy-2(5H)-furanones; 5-(2-arylthio)ethyl-3,4-dihydroxy-2(5H)-furanones; and 5-(2-aryloxy)ethyl-3,4-dihydroxy-2(5H)-furanones. This invention further relates to the use of the above mentioned compounds as anti-inflammatory agents through their action as mixed inhibitors of lipid peroxidation, 5-lipoxygenase, cyclooxygenase-1 and cyclooxygenase-2. The invention further relates to the use of such compounds in the treatment of chronic inflammatory disorders such as asthma, rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, acute respiratory distress syndrome, and central nervous system disorders such as Alzheimer's and Parkinson's disease wherein reactive oxygen species and inflammatory mediators are contributing deleterious factors.
