6246-99-7

Upstream product

• 463-49-0 1,2-propanediene 
• 622-37-7 Phenyl azide 
• 13837-45-1 1-ethoxy-1-cyclopropanol 
• 62-53-3 aniline 
• 67-56-1 methanol 
• 27374-25-0 [(1-Ethoxycyclopropyl)oxy]trimethylsilane 

Relevant academic research and scientific papers

Practical Synthesis of N-Cyclopropylanilines via Direct Condensation of Anilines with [(1-Ethoxycyclopropyl)oxy]trimethylsilane

N-Cyclopropylanilines were obtained in high yield through the condensation reaction of anilines with [(1-ethoxycyclopropyl)oxy]trimethylsilane by a simple two-steps operating process, without purification of the intermediate, 1-alkoxy-1-anilinocyclopropane.

Aryl Azide-Allene Cycloaddition. The Contrasting Behavior of Two Simple Allenes, 1,2-Cyclononadiene and 1,2-Propadiene

1,2-Cyclononadiene (1) reacts with phenyl azide (2a) and 4-bromophenyl azide (2b) to give conjugated triazoline adducts 3a and 3b, respectively. (R)-(+)-1 and 2a react to give (S)-(+)-3a, which is consistent with a concerted cycloaddition mechanism.The reaction of 1,2-propadiene (6) and 2a gives triazoles 8 and 10 plus compound 18 in nearly equal amounts.The formation of these products is rationalized by a scheme involving initial formation of triazolines 7 and 9.Triazoline 3a is slowly isomerized by sodium ethoxide or N,N-dimethylaniline to triazole 20.