62495-39-0

Usage

Preparation

Preparation by reaction of dimethyl sulfate with 2,4′-dihydroxy-3′,4,5′- trimethoxybenzophenone in the pres ence of potassium carbonate in refluxing acetone for 30 min (57%).

Upstream product

• 55744-84-8 2,3',4,4',5'-Pentamethoxybenzophenon 
• 2675-79-8 1-bromo-3,4,5-trimethoxybenzene 
• 1027525-99-0 [2-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-(3,4,5-trimethoxy-phenyl)-methanone 

Downstream Products

• 154094-10-7 3,4,4',5-tetramethoxy-2'-(dimethylaminocarbonyloxythio)-benzophenone 
• 154094-11-8 3,4,4',5-tetramethoxy-2'-mercaptobenzophenone 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents

A new type of inhibitor of tubulin polymerization was discovered on the basis of the combretastatin molecular skeleton. The lead compounds in this series, compounds 6 and 7, strongly inhibited tubulin polymerization in vitro and significantly arrested cel

Synthesis and Chemistry of Thia-analogs of the Anti-mitotic Podophyllium Lignans

The Michael-aldol product (8) from PhSH-PhCHO-2(5H)-furanone is converted by acids to the tricyclic compound (9), without the intermediacy of the olefin (10).The podophyllotoxin analog (22) was similarly obtained.The all-trans compounds were isomerised by DBU to the cis lactones.Hydroxylated analogs (26) and (33) were produced by reacting 2-(5H)-furanone with appropriate 2-mercaptobenzophenones.Thermal rearrangement of the sulfoxide (35) initially gave the spirocyclic isomer (37), then formed dimeric products on prolonged heating.