625445-17-2Relevant academic research and scientific papers
Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors
Li, Hui,Tatlock, John,Linton, Angelica,Gonzalez, Javier,Borchardt, Allen,Dragovich, Peter,Jewell, Tanya,Prins, Tom,Zhou, Ru,Blazel, Julie,Parge, Hans,Love, Robert,Hickey, Michael,Doan, Chau,Shi, Stephanie,Duggal, Rohit,Lewis, Cristina,Fuhrman, Shella
, p. 4834 - 4838 (2007/10/03)
A novel class of non-nucleoside HCV NS5B polymerase inhibitors has been identified from screening. A co-crystal structure revealed an allosteric binding site in the protein that required a unique conformational change to accommodate inhibitor binding. Her
INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME
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Page/Page column 18, (2010/02/07)
Compounds of formula (I) are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus.
