625446-00-6Relevant academic research and scientific papers
Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors
Li, Hui,Tatlock, John,Linton, Angelica,Gonzalez, Javier,Borchardt, Allen,Dragovich, Peter,Jewell, Tanya,Prins, Tom,Zhou, Ru,Blazel, Julie,Parge, Hans,Love, Robert,Hickey, Michael,Doan, Chau,Shi, Stephanie,Duggal, Rohit,Lewis, Cristina,Fuhrman, Shella
, p. 4834 - 4838 (2007/10/03)
A novel class of non-nucleoside HCV NS5B polymerase inhibitors has been identified from screening. A co-crystal structure revealed an allosteric binding site in the protein that required a unique conformational change to accommodate inhibitor binding. Her
