625457-56-9

Basic information

• Product Name: (R)-ethyl 4-[(tert-butoxycarbonyl)amino]-3-(4-chlorophenyl)butanoate
• Synonyms: (R)-ethyl 4-[(tert-butoxycarbonyl)amino]-3-(4-chlorophenyl)butanoate
• CAS NO: 625457-56-9
• Molecular Weight: 341.835
• Mol File: 625457-56-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-ethyl 4-[(tert-butoxycarbonyl)amino]-3-(4-chlorophenyl)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-ethyl 4-[(tert-butoxycarbonyl)amino]-3-(4-chlorophenyl)butanoate(625457-56-9)
• EPA Substance Registry System: (R)-ethyl 4-[(tert-butoxycarbonyl)amino]-3-(4-chlorophenyl)butanoate(625457-56-9)

Safety Data

• Hazardous Substances Data: 625457-56-9(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 89711-08-0 N-(t-butoxycarbonyl)glycinal 
• 26690-80-2 2-(N-tert-butoxycarbonylamino)ethanol 
• 1679-18-1 4-Chlorophenylboronic acid 
• 104700-36-9 ethyl (2E)-4-[(tert-butoxycarbonyl)amino]but-2-enoate 

Downstream Products

• 69308-37-8 (R)-baclofen 

Relevant articles and documents

Enantioselective Syntheses of (-)-(R)-Rolipram, (-)-(R)-Baclofen and Other GABA Analogues via Rhodium-Catalyzed Conjugate Addition of Arylboronic Acids

Highly enantioselective syntheses of two important γ-aminobutyric acid (GABA) analogues, the antispastic drug (-)-(R)-Baclofen and the antidepressant agent (-)-(R)-Rolipram, are reported. Key-steps in both syntheses are the Rh-catalyzed asymmetric 1,4-additions of arylboronic acids to 4-aminobut-2,3-enoic acid derivatives.