625457-56-9Relevant academic research and scientific papers
Enantioselective Syntheses of (-)-(R)-Rolipram, (-)-(R)-Baclofen and Other GABA Analogues via Rhodium-Catalyzed Conjugate Addition of Arylboronic Acids
Becht, Jean-Michel,Meyer, Oliver,Helmchen, Guenter
, p. 2805 - 2810 (2007/10/03)
Highly enantioselective syntheses of two important γ-aminobutyric acid (GABA) analogues, the antispastic drug (-)-(R)-Baclofen and the antidepressant agent (-)-(R)-Rolipram, are reported. Key-steps in both syntheses are the Rh-catalyzed asymmetric 1,4-additions of arylboronic acids to 4-aminobut-2,3-enoic acid derivatives.
Enantioselective synthesis of (-)-(R)-Baclofen and analogues via rhodium-catalysed conjugate addition of boronic acids
Meyer, Oliver,Becht, Jean-Michel,Helmchen, Günter
, p. 1539 - 1541 (2007/10/03)
Highly enantioselective syntheses of the antispastic drug (-)-(R)-Baclofen and analogues have been achieved by using rhodium-catalysed asymmetric 1,4-additions of arylboronic acids to 4-amino-but-2,3-enoic acid derivatives.
