62550-65-6

Usage

Uses

Used in Pharmaceutical Research and Development:
Ethyl 3-(Naphthalen-7-Yl)-3-Oxopropanoate is utilized as a building block in the creation of a diverse range of drugs and pharmaceutical compounds. Its chemical structure allows for the development of new medications, contributing to advancements in healthcare and medicine.
Used in Organic Synthesis:
In the field of organic synthesis, Ethyl 3-(Naphthalen-7-Yl)-3-Oxopropanoate is employed as a reagent or intermediate. This role is crucial for the production of other organic compounds, highlighting its importance in the synthesis of complex organic molecules.
Used in Biological and Pharmacological Studies:
Ethyl 3-(Naphthalen-7-Yl)-3-Oxopropanoate is also studied for its potential biological and pharmacological properties. This research is vital for understanding its possible applications in medicine and the development of new therapeutic agents.

Upstream product

• 93-08-3 methyl 2-naphthyl ketone 
• 105-58-8 Diethyl carbonate 
• 1071-46-1 hydrogen ethyl malonate 
• 2243-83-6 2-naphthaloyl chloride 
• 3007-91-8 ethyl-2-naphthoate 
• 141-78-6 ethyl acetate 
• 6148-64-7 ethyl potassium malonate 
• 93-09-4 naphthalene-2-carboxylate 
• 141545-26-8 ethyl 3-hydroxy-3-(naphthalen-2-yl)propanoate 
• 66-99-9 β-naphthaldehyde 
• 623-73-4 diazoacetic acid ethyl ester 
• 109090-32-6 2-[2]naphthoyl-3-oxo-butyric acid ethyl ester 

Downstream Products

• 78120-48-6 3-[2]naphthyl-3-oxo-propionic acid anilide 
• 83777-15-5 2,4-Dihydroxy-6-naphthalen-2-yl-benzoic acid ethyl ester 
• 223690-27-5 ethyl 5-(2-methoxy-1-phenyl-2-t-butyldimethylsilyloxy-cyclopropyl)-2-(2-naphthoyl)pentanoate 
• 261730-55-6 ethyl 3-amino-3-(2-naphthyl)-2-propenoate 
• 261730-55-6 ethyl 3-amino-3-(naphthalen-2-yl)acrylate 
• 690958-68-0 1-(biphenyl-4'-yl)-3-(2-naphthyl)propane-1,3-dione 
• 223690-28-6 4-(2-methoxy-1-phenyl-2-t-butyldimethylsilyloxy-cyclopropyl)butyl 2-naphthyl ketone 
• 1236923-63-9 C₂₂H₁₇NO₅ 
• 1333320-97-0 ethyl 2-acetoxy-3-(4-methoxyphenylamino)-3-(naphthalen-2-yl)acrylate 
• 1321625-30-2 3-(2-naphthoyl)-6-phenyl-4-propyl-2H-pyran-2-one 
• 1401169-56-9 N-(4-chlorophenyl)-2-[6,7-methylenedioxy-3-(2-naphthoyl)-4-oxo-1-quinolinyl]-acetamide 

Relevant academic research and scientific papers

Trifluoroethanol as a Unique Additive for the Chemoselective Electrooxidation of Enamines to Access Unsymmetrically Substituted NH-Pyrroles

An electrochemical method for the synthesis of unsymmetrically substituted NH-pyrroles is described. The synthetic strategy comprises a challenging heterocoupling between two structurally diverse enamines via sequential chemoselective oxidation, addition,

Cooperative Hydrogen-Bond-Donor Catalysis with Hydrogen Chloride Enables Highly Enantioselective Prins Cyclization Reactions

Cooperative asymmetric catalysis with hydrogen chloride (HCl) and chiral dual-hydrogen-bond donors (HBDs) is applied successfully to highly enantioselective Prins cyclization reactions of a wide variety of simple alkenyl aldehydes. The optimal chiral cata

Electrochemical Oxidative Cyclization: Synthesis of Polysubstituted Pyrrole from Enamines

A conceptually novel method for the preparation of pyrrole is described by electrochemical-oxidation-induced intermolecular annulation via enamines. In a simple undivided cell, based on a sodium acetate-facilitated, polysubstituted pyrrole derivations has been facilely synthesized under external oxidant-free condition. This electrosynthetic approach providing an environmentally benign protocol for C?C bond cross-coupling and oxidative annulation, which features unparalleled broad scope of substrates and practicality.

Construction of isoxazolone-fused phenanthridinesviaRh-catalyzed cascade C-H activation/cyclization of 3-arylisoxazolones with cyclic 2-diazo-1,3-diketones

A Rh(iii)-catalyzed cascade C-H activation/intramolecular cyclization of 3-aryl-5-isoxazolones with cyclic 2-diazo-1,3-diketones was described, leading to the formation of isoxazolo[2,3-f]phenanthridine skeletons. The protocol features the simultaneous one-pot formation of two new C-C/C-N bonds and one heterocycle in moderate-to-good yields with good functional group compatibility. It is amenable to large-scale synthesis and further transformation.

Sulfur-controlled and rhodium-catalyzed formal (3 + 3) transannulation of thioacyl carbenes with alk-2-enals and mechanistic insights

A rhodium-catalyzed denitrogenative formal (3 + 3) transannulation of 1,2,3-thiadiazoles with alk-2-enals is achieved, producing 2,3-dihydrothiopyran-4-ones in moderate to excellent yields. An inverse KIE of 0.49 is obtained, suggesting the reversibility of the oxidative addition of thioacyl Rh(i) carbenes to alk-2-enals. The late-stage structural modifications of steroid compounds are realized. Moreover, our studies show that thioacyl carbenes have different reactivities to those of α-oxo and α-imino carbenes, and highlight the importance of heteroatoms in deciding the reactivities of heterovinyl carbenes.

Aromaticity-Driven Access to Cycloalkyl-Fused Naphthalenes

We report the efficient synthesis of cycloalkyl-fused naphthalenes through the [4 + 2]-cycloaddtion/decarboxylative aromatization of alkyne-tethered aryne insertion adducts. These scaffolds were difficult to synthesize using conventional reactions. The reaction proceeds via the formation of a benzopyrylium intermediate followed by intramolecular [4 + 2] cycloaddition and a subsequent decarboxylation pathway. This method is also compatible with allene-tethered substrates to afford similar products. In addition, the one-pot synthesis of polysubstituted naphthalenes via aryne insertion/benzannulation has also been developed in good yield.

Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of Racemic β’-Keto-β-Amino Esters via Dynamic Kinetic Resolution

An iridium/f-diaphos catalytic system for the enantioselective hydrogenation of α-substituted β-ketoesters via dynamic kinetic resolution is reported. The desired anti β’-hydroxy-β-amino esters were obtained in moderate to good yields (60–95%) with 72–99% ees and 91:9 to 99:1 drs. This protocol tolerates various functional groups and could be easily conducted on gram scale with lower catalyst loading (TON up to 9100). (Figure presented.).

Amide/Ester Cross-Coupling via C-N/C-H Bond Cleavage: Synthesis of β-Ketoesters

Activated primary, secondary, and tertiary amides were coupled with enolizable esters in the presence of LiHMDS to obtain good yields of β-ketoesters at room temperature. Notably, this protocol provides an efficient, mild, and high chemoselectivity method

Radical Aza-Cyclization of α-Imino-oxy Acids for Synthesis of Alkene-Containing N-Heterocycles via Dual Cobaloxime and Photoredox Catalysis

Nitrogen-containing heterocycles are prevalent in both naturally and synthetically bioactive molecules. We report herein an unprecedented protocol for radical aza-cyclization of α-imino-oxy acids with pendant alkenes via synergistic photoredox and cobaloxime catalysis. With or without alkenes as the intermolecular cross-coupling partners, the transformation provides a variety of corresponding alkene-containing dihydropyrrole products in satisfactory yields. In the presence of external alkenes, the tandem reaction generates E-selective coupling products with excellent chemo- and stereoselectivity.

An efficient route for the synthesis of N-(1H-benzo[d]imidazol-2-yl)benzamide derivatives promoted by CBr4 in one pot

A metal-free one-pot method for the synthesis of N-(1H-benzo[d]imidazol-2-yl)benzamide derivatives was proposed mediated by CBr4. The reaction went through ring formation and opening processes with only two protons leaving and the thermodynamically favorable products were selectively formed in moderate to good yields.