62559-41-5Relevant academic research and scientific papers
THE CYCLISATION AND REARRANGEMENT OF THE NITRO DERIVATIVES OF AROMATIC HYDROCARBONS IN TRIFLUOROMETHANESULPHONIC ACID
Bullen, John V.,Ridd, John H.,Sabek, Omaima
, p. 291 - 296 (2007/10/02)
A number of the nitro derivatives of aromatic hydrocarbons undergo reactions in trifluoromethanesulphonic acid at ca. 100 deg C in which either the nitro group undergoes a 1,3-rearrangement or cyclisation occurs to form an anthranil.The rates and product composition have been determined for reactions in which the subsituents ortho to the nitro group are methyl or ethyl.For the rearrangement reaction to occur, it appears necessary that the nitro group should be initially between two alkyl substituents.The cyclisation reaction is significant only when one of the ortho-substituents is an ethyl group.
ipso Nitration. XXIII. Reactions of cyclohexadiene adducts from nitration of 4-ethyltoluene in acetic anhydride
Fischer, Alfred,Henderson, George N.
, p. 2314 - 2327 (2007/10/02)
The diastereoisomers of 4-ethyl-1-methyl-4-nitrocyclohexa-2,5-dienyl acetate (1) and 1-ethyl-4-methyl-4-nitrocyclohexa-2,5-dienyl acetate (2) are stereospecifically reduced to the corresponding nitrocyclohexadienols with aluminum hydride.Each dienol is stereospecifically methylated to the corresponding methyl ether with methyl iodide, silver oxide, and potassium hydroxide.Acid-catalysed solvolysis of the acetates 1 and 2 results in the substitution of the acetate moiety by other nucleophiles and these reactions are not stereospecific.The products of rearomatization of dienyl acetates, dienols and dienyl methyl ethers depend on the acidity and ionizing power of the solvents and are readily explained in terms of reactions involving a nitrocyclohexadienyl cation or acetoxy- (hydroxy-, methoxy-)cyclohexadienyl cation as key intermediates.In the 4-acetoxy-4-alkylcyclohexadienyl cation 1,2-migration of the acetoxyl group is more rapid then alkyl migration, but 1,2-alkyl migration is faster then migration of the hydroxyl or methoxyl groups in the corresponding cations. 1-Ethyl-4-methoxy-4-methylcyclohexa-2,5-dien-1-ol and 4-ethyl-3-nitrotoluene are significant minor products in the solvolysis of 1-ethyl-4-methyl-4-nitrocyclohexa-2,5-dien-1-ol in aqueous methanol.Nitration of p-ethyltoluene in the presence of sulfuric acid or in trifluoracetic anhydride gives a mixture of 4-ethyl-2-nitro- and 4-ethyl-3-nitrotoluene in a 2:1 ratio.
